Results 171 to 180 of about 1,495,900 (311)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Measuring quality of life in autistic children and young people: comparing the performance of common generic health related quality of life instruments. [PDF]

Qual Life Res
Constable L, O'Loughlin R, Jones R, Hiscock H, Dalziel K, Quality of Life in Kids: Key evidence to strengthen decisions in Australia (QUOKKA) project team.   +5 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Development and Psychometric Validation of a Usability Instrument Based on ISO 25010 for Electronic Health Record Systems in Peruvian Health Care Settings: Methodological Study. [PDF]

JMIR Hum Factors
Mamani-Pari D, Peñaloza-Hualpa AF, Humpiri-Flores ME, Gutierrez-Quispe E, Otazu-Luque JE.   +4 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Measuring University Web Site Quality: A Development of a User-Perceived Instrument and its Initial Implementation to Web sites of Accounting Departments in New Zealand's Universities [PDF]

The emergent popularity of Web technologies and their applications have created vast opportunities for organisations, including institutions of higher education, to stretch out for broader customers and create greater networking relationships. The global
Hadrian Djajadikerta, Terri Trireksani
core  

Eye-hand coordination during robotic prostate cancer surgery - how surgical vision reflects on instrument kinematics and vice versa. [PDF]

J Robot Surg
Pirkovets K, Ottens VA, van Oosterom MN, van der Poel HG, van Leeuwen FWB.   +4 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Development and psychometric evaluation of the Patient Safety Culture in Home Health Care Centers Instrument (PSCHCI): a sequential exploratory mixed-methods protocol in Iran. [PDF]

BMJ Open
Etebarian Khorasgani A, Ashghali Farahani M, Sharif-Nia H, Gholami M, Golestan F, Ghezeljeh TN.   +5 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source