Results 201 to 210 of about 4,143,589 (309)

Repurposing drugs for the prevention of vascular dementia using evidence from drug target Mendelian randomization. [PDF]

Nat Aging
Taylor-Bateman V, Bothongo P, Walker V, Kehoe PG, Nordestgaard LT, Ben-Shlomo Y, Davies NM, Williams DM, Anderson EL.   +8 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Development and Psychometric Testing of the Optimizing Context in Assessing Sedation in ICU (OCEAN-ICU) Instrument to Optimize Sedation Use in Intensive Care. [PDF]

Crit Care Explor
Aitken LM, Castro-Avila A, Dyson J, Kydonaki K, Blackwood B, Iliopoulou K, McKenzie C, Walsh TS.   +7 more
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

The effects of the forgetting curve in the training of knee arthroplasty surgical instrument nurses: a pilot randomized controlled trial. [PDF]

BMC Nurs
Zhang L, Chen S, Liang Q, Wang S, Han Z, Huang J, Zhang Z.   +6 more
europepmc   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Design and validation of a bioethical assessment instrument for public health policies involving behavioral change: A mixed-methods study. [PDF]

Public Health Pract (Oxf)
Martínez AC, Aristizábal Castrillón P, Lopez Erazo LJ, Montoya Villegas M, Tamayo LA, Montagut Ascanio M, Borda JP, Lasso EF.   +7 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Development and Initial Psychometric Testing of a Patient-Reported Clinical Tool for Endometriosis: The Mobility Measure for Endometriosis (MobEndo). [PDF]

J Clin Med
Montilla-Herrador J, Gacto-Sánchez M, Lozano-Meca J, Martínez-González M, Marín Sánchez MP, Medina-Mirapeix F.   +5 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source