Results 241 to 250 of about 1,472,859 (309)

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Fostering Research Integrity through Training: The training materials of four EU-funded projects through the lens of pedagogical underpinnings and three taxonomies of learning. [PDF]

Open Res Eur
Löfström E, Lindemann T, Blom F, Evans N, van den Hoven M, Inguaggiato G, Kavouras P, Lanzerath D, Priess-Buchheit J, Santos R, Tammeleht A, Wall PJ, Zollitsch L.   +12 more
europepmc   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Facilitators and Barriers to Implementing Research Integrity Code of Conduct and Open Science Initiatives: Perspectives of Research Regulators in Kenya, Malawi and Uganda

Barugahare J, Kumwenda T, Mfutso-Bengo J, Kamuyu R, Bukusi E, Sseryazi IS, Mutumba B, Opolot H, Zeegers M, Gopalakrishna G.   +9 more
europepmc   +1 more source

Cairo Consensus Statement on Research Integrity of Randomised Clinical Trials. [PDF]

Pak J Med Sci
Chien PF, Khan KS, Fawzy M, Khalaf Y, Cairo Consensus Group on Research Integrity.   +4 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Research integrity in the era of artificial intelligence: Challenges and responses. [PDF]

Medicine (Baltimore)
Chen Z, Chen C, Yang G, He X, Chi X, Zeng Z, Chen X.   +6 more
europepmc   +1 more source

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

Integrating survivors with frontline trauma providers: a winning strategy for providers, survivors, and research integrity. [PDF]

Trauma Surg Acute Care Open
Newcomb A, Ritter GS.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source