Results 161 to 170 of about 2,405,022 (374)
Current Trends in the Development of Science: Problems of Interdisciplinarity
Ekonomika NaukiThis article examines current trends in interdisciplinary research, driven by dual imperatives: societal and economic demands for practical solutions, and the intrinsic evolution of scientific inquiry.
L. P. Kleeva
doaj
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
The hunt for the last relevant paper: blending the best of humans and AI
European Journal of PsychotraumatologyBackground: The exponential growth of research literature makes it increasingly difficult to identify all relevant studies for systematic reviews and meta-analyses.
Rens van de Schoot +14 more
doaj +1 more source
, 2015 This paper outlines a course to integrate digital visualizations into undergraduate research. These visualizations will include mapping and timelines of events, and the ability to hyperlink the events, characters, and story lines in a fantasy fiction ...
Kann, Charles W.
core
Need-achievement, expectations and life purpose: A french-argentine study of PhDs in education [PDF]
, 2017 Here we present a comparative research study of doctoral programs in the social sciences in Argentina and France (2009-2017). The focus is to analyze professional pathways and their relationship to base, socio-cultural, psychosocial and structural ...
Aparicio, Miriam Teresita
core
Identifying prognostic targets in metastatic prostate cancer beyond AR
FEBS Open Bio, EarlyView.Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng +13 more
wiley +1 more source
Microfluidic electro‐viscoelastic manipulation of extracellular vesicles
FEBS Open Bio, EarlyView.The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh +7 more
wiley +1 more source
BMC GeriatricsBackground Urinary incontinence (UI) is a common geriatric syndrome with high health and socio-economic impacts in nursing home (NH) residents. Objectives To estimate the prevalence and types of UI and its associated factors in older people living in NHs
Javier Jerez-Roig +11 more
doaj +1 more source
A typology of research methods within the Social Sciences [PDF]
, 2004 This paper discusses and develops a typology of research methods in the social sciences. Such a typology will be relevant for various aspects of the work of the ESRC National Centre for Research Methods (NCRM) as well as other ESRC initiatives and the ...
Beissel-Durrant, Gabriel
core
Two‐way inhibition of PAX5 transcriptional activity by PAX5::CBFA2T3
FEBS Open Bio, EarlyView.PAX5::CBFA2T3 (PAX5‐C) is a fusion protein of the B‐cell transcription factor, PAX5, and is found in B‐cell ALL. We propose a putative model of two‐way inhibition of PAX5 transcriptional activity by PAX5‐C. There are two ways of repression by PAX5‐C: DNA‐binding‐dependent way and HDAC‐dependent way, with either being sufficient for the repression. HDAC
Reina Ueno +12 more
wiley +1 more source