Results 181 to 190 of about 1,735,729 (314)

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

Methodology as Pedagogy: Trans Lives, Social Science, and the Possibilities of Education Research [PDF]

, 2022
Harper B. Keenan
openalex   +1 more source

Characterisation of the role played by ELMO1, GPR141 and the intergenic polymorphism rs918980 in Fuchs' dystrophy in the Indian population

FEBS Open Bio, EarlyView.
This study reports the upregulation of ELMO1 and GPR141 in human Fuchs' endothelial corneal dystrophy (FECD) corneal endothelium and ultraviolet A‐induced FECD mice model. A genetic association of an intergenic single nucleotide polymorphism rs918980 present between both genes is observed with FECD in the Indian population.
Susmita Sharma, Samar Kumar Basak, Sujata Das, Debasmita Pankaj Alone   +3 more
wiley   +1 more source

Prevalence of urinary incontinence and associated factors in nursing homes: a multicentre cross-sectional study

BMC Geriatrics
Background Urinary incontinence (UI) is a common geriatric syndrome with high health and socio-economic impacts in nursing home (NH) residents. Objectives To estimate the prevalence and types of UI and its associated factors in older people living in NHs
Javier Jerez-Roig, Pau Farrés-Godayol, Meltem Yildirim, Anna Escribà-Salvans, Pau Moreno-Martin, Ester Goutan-Roura, Sandra Rierola-Fochs, Montse Romero-Mas, Joanne Booth, Dawn A. Skelton, Maria Giné-Garriga, Eduard Minobes-Molina   +11 more
doaj   +1 more source

A non‐fluorescent immunohistochemistry method for measuring autophagy flux using MAP1LC3/LC3 and SQSTM1 as core markers

FEBS Open Bio, EarlyView.
We introduce an immunohistochemistry method to measure autophagy flux, highlighting the active degradation and recycling of cellular waste. This cost‐effective approach uses tissue samples to track key markers like LC3 and SQSTM1, revealing how cells maintain health or respond to diseases such as cancer. It bridges the gap between research and clinical
Shahla Shojaei, Amir Barzegar Behrooz, Marco Cordani, Mahmoud Aghaei, Negar Azarpira, Daniel J. Klionsky, Saeid Ghavami   +6 more
wiley   +1 more source

Search advantages for facing social groups reflect optimal interactive group sizes

iScience
Summary: Humans are sensitive to the presence of other people as well as their interactions. For example, two individuals are found faster when they face toward (vs. away from) each other.
Luowei Yan, Clara Colombatto, Jelena Ristic   +2 more
doaj  

Revisión bibliográfica. Lesiones en el deporte: bíceps braquial y voleibol [PDF]

, 2014
Objective: The main objective of this review was to assess the prevalence of lesions in the brachial biceps in volleyball players, as well as review the different prevention measures and procedures that are used in this treatment myocardial structure ...
Díaz Sotero, Silvia
core   +1 more source

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Social Scientists\u27 Conceptualization and Implementation of Research Ethics and Integrity [PDF]

, 2018
The purpose of the current study is to identify core themes, values, and principles through which social scientists conceptualize and implement research ethics and integrity.
Pease, Heather A.
core   +1 more source

Non-Equilibrium Social Science and Policy: Introduction and Essays on New and Changing Paradigms in Socio-Economic Thinking [PDF]

Data-driven Science, Modeling and Theory Building; Methodology of the Social Sciences; Economic Theory/Quantitative Economics/Mathematical Methods; Operation Research/Decision Theory ...

core   +1 more source