A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento +3 more
wiley +1 more source
Public-private mix in health systems and repercussions for health inequalities in Latin American countries: A scoping review protocol. [PDF]
Ferreira Dos Anjos E +14 more
europepmc +1 more source
ABSTRACT Background X‐linked adrenoleukodystrophy (X‐ALD) is a neurometabolic disorder caused by pathogenic variants in ABCD1, leading to slowly progressive spinal cord disease in nearly all affected men. Sensitive biomarkers to quantify disease severity and predict progression are needed for clinical care and trial design.
Eda G. Kabak +4 more
wiley +1 more source
Socioeconomic determinants of shift work employment in Canada and the Netherlands: a cross-sectional analysis of data from the Canadian Longitudinal Study on Aging and the Hoorn Study. [PDF]
Campbell DB +12 more
europepmc +1 more source
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan +5 more
wiley +1 more source
The mediating role of quality of life in the relationship between teachers' participation in physical activity and empathic and social self-efficacy. [PDF]
Turhan MO +9 more
europepmc +1 more source
Philosophical Reflections on Research Methodology for Social Sciences
openaire +1 more source
ABSTRACT Objective This study aimed to investigate the immunological response to influenza vaccination, the incidence and severity of influenza infection, and the side effects of the vaccination in patients with ischemic stroke. Methods This prospective observational study was conducted between 2023 and 2024 at Ramathibodi Hospital.
Achiraya Pakngao +5 more
wiley +1 more source
Global Evidence on Helmet Use and Misuse: A Public Health Perspective on Prevalence, Determinants and Barriers. [PDF]
Rezapour R +5 more
europepmc +1 more source

