Results 61 to 70 of about 52,837,615 (296)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Do you have a communication disability?
, 2019 "Publication date: 12/18"--Unnumbered page
Opportunities for Ohioans with Disabilities
core
“Don’t I need research to get a residency?” Incorporating scholarly activity at a regional campus
Journal of Regional Medical CampusesThe impact of Step 1 becoming pass-fail is yet to be known. Many believe the value and power of scholarly activity will increase across specialties, but opportunities for such activities differ across universities and even between campuses.
Alexis Ruppel +1 more
doaj +1 more source
Frontiers in Sociology, 2019 Despite growing public awareness and policy efforts, gender equality has not yet been fully established in Western societies. Previous research has shown that hostile and benevolent sexist attitudes, which are grounded in traditional gender stereotypes ...
Laora Mastari +2 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
The Pacific research paradigm: opportunities and challenges
, 2019 Around the world, favourable social and political circumstances have encouraged the development of academically non-traditional ways of researching.
McFall-McCaffery, Judy +1 more
core +1 more source
Advancing genomics research in Ireland: Part Two. Irish Health Research Forum report and recommendations [PDF]
, 2021 This report presents the proceedings of the Irish Health Research Forum on 12th May 2021. This is the second report to focus on advancing genetics and genomics in Ireland, and makes key recommendations for health research policy and practice in ...
Health Research Charities Ireland
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source