Results 121 to 130 of about 25,911 (248)

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

Beyond target chemicals: updating the NORMAN prioritisation scheme to support the EU chemicals strategy with semi-quantitative suspect/non-target screening data

Environmental Sciences Europe
Background Prioritisation of chemical pollutants is a major challenge for environmental managers and decision-makers alike, which is essential to help focus the limited resources available for monitoring and mitigation actions on the most relevant ...
Valeria Dulio, Nikiforos Alygizakis, Kelsey Ng, Emma L. Schymanski, Sandrine Andres, Katrin Vorkamp, Juliane Hollender, Saskia Finckh, Reza Aalizadeh, Lutz Ahrens, Elodie Bouhoulle, Ľuboš Čirka, Anja Derksen, Geneviève Deviller, Anja Duffek, Mar Esperanza, Stellan Fischer, Qiuguo Fu, Pablo Gago-Ferrero, Peter Haglund, Marion Junghans, Stefan A. E. Kools, Jan Koschorreck, Benjamin Lopez, Miren Lopez de Alda, Giuseppe Mascolo, Cécile Miège, Leonard Osté, Simon O’Toole, Pawel Rostkowski, Tobias Schulze, Kerry Sims, Laetitia Six, Jaroslav Slobodnik, Pierre-François Staub, Gerard Stroomberg, Nikolaos S. Thomaidis, Anne Togola, Giorgio Tomasi, Peter C. von der Ohe   +39 more
doaj   +1 more source

Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation. [PDF]

Pharmacogenomics J, 2020
King C, McKenna A, Farzan N, Vijverberg SJ, van der Schee MP, Maitland-van der Zee AH, Arianto L, Bisgaard H, BØnnelykke K, Berce V, PotoČnik U, Repnik K, Carleton B, Daley D, Chew FT, Chiang WC, Sio YY, Cloutier MM, Den Dekker HT, Duijts L, de Jongste JC, Dijk FN, Flores C, Hernandez-Pacheco N, Mukhopadhyay S, Basu K, Tantisira KG, Verhamme KM, Celedón JC, Forno E, Canino G, Francis B, Pirmohamed M, Sinha I, Hawcutt DB.   +34 more
europepmc   +1 more source

Safety and Efficacy of GLP‐1 Receptor Agonists in Adults With Epilepsy, Obesity, and Type 2 Diabetes

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Managing obesity in patients with epilepsy is complicated by the weight‐gaining properties of essential antiseizure medications (ASMs) such as valproate and pregabalin. We evaluated the safety and efficacy of initiating glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) in this population.
Hyoshin Son, Inyoung Hwang, Sang Won Lee, Yun Kim   +3 more
wiley   +1 more source

Harnessing inter-disciplinary collaboration to improve emergency care in low- and middle-income countries (LMICs): results of research prioritisation setting exercise. [PDF]

BMC Emerg Med, 2020
Lecky FE, Reynolds T, Otesile O, Hollis S, Turner J, Fuller G, Sammy I, Williams-Johnson J, Geduld H, Tenner AG, French S, Govia I, Balen J, Goodacre S, Marahatta SB, DeVries S, Sawe HR, El-Shinawi M, Mfinanga J, Rubiano AM, Chebbi H, Do Shin S, Ferrer JME, Haddadi M, Firew T, Taubert K, Lee A, Convocar P, Jamaluddin S, Kotecha S, Yaqeen EA, Wells K, Wallis L.   +32 more
europepmc   +1 more source

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin, Yue Andy Qi, Ying Hao, Catherine DeMarino, Samuel Darko, Irene Cortese, Daniel S. Reich, María I. Gaitán, Steven Jacobson, Bridgett J. Billioux, Bryan Smith, Avindra Nath   +11 more
wiley   +1 more source

Collecting perspectives on project prioritisation process in the EU co-funded multinational partnership for the assessment of risks from chemicals (PARC) through focus group discussion

Environmental Sciences Europe
Introduction The European Partnership for the Assessment of Risks from Chemicals (PARC) is a 7-year multinational partnership aimed at consolidating and strengthening European Union’s (EU) research and innovation capacity for chemical risk assessment (RA)
Katya Manuella Permana, Maria Tannous, Hanna Mouaziz, Pascal Sanders, Nathalie Bonvallot, Christophe Rousselle   +5 more
doaj   +1 more source

Identifying integrated health services and social care research priorities in kidney disease in Wales: research prioritisation exercise. [PDF]

BMJ Open, 2020
Mc Laughlin L, Spence S, Noyes J.
europepmc   +1 more source

Retractions in Rheumatology: Trends, Causes, and Implications for Research Integrity

Arthritis Care &Research, EarlyView.
Objective We aimed to describe the trends and main reasons for study retraction in rheumatology literature. Methods We reviewed the Retraction Watch database to identify retracted articles in rheumatology. We recorded the main study characteristics, authors’ countries, reasons for retraction, time from publication to retraction, and trends over time ...
Anna Maria Vettori, Michele Iudici
wiley   +1 more source