Results 161 to 170 of about 255,660 (218)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Quality of Research

Journal of Obstetric, Gynecologic & Neonatal Nursing, 1990
openaire   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source

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The Quality of Qualitative Research

American Journal of Medical Quality, 2008
In general, an appreciation of the standards of qualitative research and the types of qualitative data analyses available to researchers have not kept pace with the growing presence of qualitative studies in medical science. To help rectify this problem, the authors clarify qualitative research reliability, validity, sampling, and generalizability ...
Dave S, Collingridge, Edwin E, Gantt
openaire   +3 more sources

Quality in qualitative research

Medical Journal of Australia, 2008
Qualitative research most commonly involves the systematic collection, ordering, description and interpretation of textual data generated from talk, observation or documentation. A report of qualitative research should address the following criteria: Clarification and justification; Procedural rigour; Representativeness; Interpretative rigour ...
Simon C, Kitto, Janice, Chesters, Carol, Grbich   +2 more
openaire   +2 more sources

Research quality: What it is, and how to achieve it

Industrial Marketing Management, 2021
Researchers are under constant pressure to publish high-quality research. What, however, constitutes high-quality research? Most universities use accepted lists of top-tier journals, citation counts, or other metrics to assess the value of research contributions. We first explore the metrics by which research contributions are evaluated.
Lindgreen, Adam, Di Benedetto, C. Anthony, Brodie, Roderick J.   +2 more
openaire   +2 more sources

Is Qualitative Research High Quality Research?

AAP Grand Rounds, 2005
Drs. Saxena and Wiedermann have disclosed no financial relationship relevant to this commentary. This commentary does not contain a discussion of an unapproved/investigative use of a commercial product/device. Because qualitative methodologies increasingly are utilized in medicine, it is important to understand these research tools.
Harshita Saxena, Bernhard L. Wiedermann
openaire   +1 more source

Achieving research quality

Researchers are under extreme pressure to publish high-quality research.What defines such research, though? Is it only research published as articlesin journals recognized worldwide as journals of distinction and exemplars ofexcellence? If so, research must be both original and courageous (Lindgreen etal., 2021c), as such research is published in the ...
Lindgreen, Adam, Di Benedetto, C. Anthony, Brodie, Roderick J., Schäfers, Tobias   +3 more
openaire   +2 more sources