Results 91 to 100 of about 8,443,323 (284)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Vexed Question of Research Priorities: An Australian Example
Prometheus, 1997 This paper discusses the nature of the research priorities debate in Australia, and traces the working out of that debate over recent years. The discussion is embedded in an account of how the institutional structure developed to allocate funds for ...
Don Aitkin
doaj +1 more source
Posing the question: an academic guide to planning essays [PDF]
, 2009 This guide will give you advice on picking your subject, question and methodology for an extended essay.
opteam,
core
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Actual Question of Telecommunication Systems and Networks Research
Advances in Electrical and Electronic Engineering, 2006 This contribution aims to inform readers about topics of scientific research performed at the Department of Radioand Communication Engineering (Kafedra radiotechniki i elektrosvjazi), the Institute of Control Systems, Telecommunications and ...
S. V. Babenko +16 more
doaj
Tips from an expert panel on the development of a clinical research protocol
BMC Medical Research MethodologyA research protocol is a document that outlines the proposed research idea and is submitted to funding agencies, institutions, or journals for approval. Writing a research protocol represents a challenge, particularly for early-career researchers.
Abdelrahman M. Makram +16 more
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Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Geochronopolitical Identity of Capitals of a Problematic Statehood: Research Question
Сравнительная политика, 2015 The article describes the methodological basis of the study of the spatial identity of the fake capital cities held a Сlub of Geopolitical Studies at ...
I. Yu. Okunev
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Player agency in interactive narrative: audience, actor & author [PDF]
, 2007 The question motivating this review paper is, how can computer-based interactive narrative be used as a constructivist learn- ing activity? The paper proposes that player agency can be used to link interactive narrative to learner agency in ...
Hammond, S., Pain, H., Smith, Tim J.
core
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source