Results 21 to 30 of about 2,932,079 (230)
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Software Engineering for Research Software
, 2019 This poster describes work at the intersection of Software Engineering and Research ...
Carver, Jeffrey C., Milewicz, Reed
openaire +1 more source
The Affect of Software Developers: Common Misconceptions and Measurements
, 2015 The study of affects (i.e., emotions, moods) in the workplace has received a lot of attention in the last 15 years. Despite the fact that software development has been shown to be intellectual, creative, and driven by cognitive activities, and that ...
Abrahamsson, Pekka +2 more
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FAIR research software development: A Research Software Engineering workflow
, 2023 We present with hands-on examples a Research Software Engineering (RSE) workflow for developing research software in Computational Science and Engineering (CSE) in university research groups. Their members have backgrounds from different scientific disciplines and often no education in RSE.
Schwarzmeier, Moritz +8 more
openaire +1 more source
Qualitative software engineering research -- reflections and guidelines
, 2020 Researchers are increasingly recognizing the importance of human aspects in software development and since qualitative methods are used to, in-depth, explore human behavior, we believe that studies using such techniques will become more common ...
Feldt, Robert +5 more
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Systems Engineering Leading Indicators Guide, Version 1.0 [PDF]
, 2013 The Systems Engineering Leading Indicators guide set reflects the initial subset of possible indicators that were considered to be the highest priority for evaluating effectiveness before the fact.
International Council on Systems Engineering +3 more
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