Results 31 to 40 of about 2,932,079 (230)
Happy software developers solve problems better: psychological measurements in empirical software engineering [PDF]
, 2014 For more than 30 years, it has been claimed that a way to improve software developers' productivity and software quality is to focus on people and to provide incentives to make developers satisfied and happy.
Abrahamsson, Pekka +2 more
core +2 more sources
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
What Makes Research Software Sustainable? An Interview Study with Research Software Engineers [PDF]
2019 IEEE/ACM 12th International Workshop on Cooperative and Human Aspects of Software Engineering (CHASE), 2019 Software is now a vital scientific instrument, providing the tools for data collection and analysis across disciplines from bioinformatics and computational physics, to the humanities. The software used in research is often home-grown and bespoke: it is constructed for a particular project, and rarely maintained beyond this, leading to rapid decay, and
de Souza, Mario Rosado +3 more
openaire +4 more sources
Systems Engineering Leading Indicators Guide, Version 2.0 [PDF]
, 2010 The Systems Engineering Leading Indicators Guide editorial team is pleased to announce the release of Version 2.0. Version 2.0 supersedes Version 1.0, which was released in July 2007 and was the result of a project initiated by the Lean Advancement ...
International Council on Systems Engineering +3 more
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Research Software Engineering @ UFZ
, 2023 A poster that presents research software engineering activities at the ...
openaire +1 more source
Guidelines for Conducting Software Engineering Research
, 2020 This chapter presents a holistic overview of software engineering research strategies. It identifies the two main modes of research within the software engineering research field, namely knowledge-seeking and solution-seeking research—the Design Science model corresponding well with the latter.
Klaas-Jan Stol, Brian Fitzgerald
openaire +2 more sources
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
Molecular Oncology, EarlyView.A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira +14 more
wiley +1 more source