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As RSEs, we apply software engineering methods, practices, and tools to research software. And despite the fact that - statistically - many of us haven’t had formal education in software engineering, we are the software experts in (academic) research in practice. It's therefore astonishing that as a community, we haven’t traditionally had strong links,
Stephan, Druskat +3 more
openaire +1 more source
Embedded Software Design for Mechatronic Systems [PDF]
, 2003 This research project is motivated by the fact that nowadays it is impossible to separate control engineering from software engineering. Besides that both of them can be found in definitions of mechatronics, this project deals with exploitation and ...
Broenink, Jan F. +2 more
core +1 more source
, 2019 Software engineering research is evolving and papers are increasingly based on empirical data from a multitude of sources, using statistical tests to determine if and to what degree empirical evidence supports their hypotheses.
Feldt, Robert +5 more
core +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Enablers and Impediments for Collaborative Research in Software Testing: An Empirical Exploration
, 2014 When it comes to industrial organizations, current collaboration efforts in software engineering research are very often kept in-house, depriving these organizations off the skills necessary to build independent collaborative research. The current trend,
Causevic, Adnan, Enoiu, Eduard Paul
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Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Better research software tools to elevate the rate of scientific discovery or why we need to invest in research software engineering. [PDF]
Front Bioinform, 2023 Deschamps J, Dalle Nogare D, Jug F.
europepmc +1 more source
An estimate of necessary effort in the development of software projects [PDF]
, 2004 International Workshop on Intelligent Technologies for Software Engineering (WITSE'04). 19th IEEE International Conference on Automated Software Engineering (Linz, Austria, September 20th - 25th, 2004)The estimated of the effort in the development of ...
Galván, Inés M. +3 more
core +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source