Results 181 to 190 of about 19,215,870 (318)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Health of South Asian migrants and refugees in Australia: an evidence gap map. [PDF]

BMJ Glob Health
Salam RA, Castleton P, Mengistu TS, Bhaumik S, Begum M, Lassi Z.   +5 more
europepmc   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Impact of digital supportive supervision (DiSS) on the extent of maternal and child healthcare service utilisation in India: a sequential mixed-methods quasi-experimental study. [PDF]

BMJ Open
Sharda S, Singh P, Trakroo A, Agrawal PK, Goyal A, Agarwal A, Chawla M, Joshi A, Singh S, Singh R, Kshtriya P, D'Aquino L, Kumar S, Prinja S.   +13 more
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Interrupted Time Series Analysis of Alcohol Use Disorder Treatment Utilisation During the Coronavirus Pandemic in Hamburg, Germany. [PDF]

Drug Alcohol Rev
Manthey J, Kilian C, Kraus L, Schranz A, Schulte B.   +4 more
europepmc   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Multi-institutional study of barriers to research utilisation and evidence-based practice among hospital nurses.

Journal of Clinical Nursing, 2009
Caroline E. Brown, L. Ecoff, S. Kim, Mary A. Wickline, Barbara Rose, Kathy Klimpel, D. Glaser   +6 more
semanticscholar   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Healthcare utilisation across five years among adolescents following metabolic-bariatric surgery; a prospective observational study. [PDF]

Lancet Reg Health Am
Beamish AJ, Jenkins T, Ryder JR, Courcoulas A, Dorman RM, Michalsky M, Harmon C, Helmrath M, Inge TH.   +8 more
europepmc   +1 more source