Results 231 to 240 of about 1,823,507 (396)

A Patient‐Derived Organoid Biobank of Adamantinomatous Craniopharyngioma as a Platform for Drug Discovery

Advanced Science, EarlyView.
This study successfully establishes adamantinomatous craniopharyngioma (ACP) patient‐derived organoids (PDOs) that preserve the histopathological and genetic features of the original tumors. Through drug sensitivity assays and subsequent mechanistic analyses, the study demonstrates that Ceritinib exerts its inhibitory effects on ACP PDO growth by ...
Huarong Zhang, Chaohu Wang, Jun Fan, Zexin Chen, Haoying Yu, Yawen Bai, Tingcheng Zhang, Qianchao Zhu, Yiwen Feng, Peirong Niu, Jiaqian Chen, Liping Yang, Xueying Li, Lei Yu, Songtao Qi, Yi Liu   +15 more
wiley   +1 more source

Techniques in coloproctology - controversies in coloproctology resection: rectopexy is an underutilised procedure in the management of both symptomatic high-grade internal and external rectal prolapse. [PDF]

Tech Coloproctol
Bunni J, Courtney ED.
europepmc   +1 more source

Development of a Predictive Nomogram for Circumferential Resection Margin in Rectal Cancer Surgery [PDF]

Megan Shroder, Molly M. Ford, Fei Ye, Zhiguo Zhao, Aimal Khan, Shannon L. McChesney, M. Benjamin Hopkins, Alexander T. Hawkins   +7 more
openalex   +1 more source

Mechanism and regulation of DNA end resection in eukaryotes

Critical reviews in biochemistry and molecular biology, 2016
L. Symington
semanticscholar   +1 more source

NEAT1 Promotes Epileptogenesis in Tuberous Sclerosis Complex

Advanced Science, EarlyView.
The primary neurological manifestations of tuberous sclerosis complex (TSC) are intractable epilepsy and intellectual disability. NEAT1 is differentially expressed in TSC‐related epilepsy and influences neuronal excitability by regulating the PI3K/AKT/mTOR signaling pathway.
Suhui Kuang, Tinghong Liu, Zhirong Wei, Jinshan Xu, Jiayi Han, Jiaqi Wang, Feng Zhai, Yiran Tian, Shuli Liang   +8 more
wiley   +1 more source

Endoscopic surgery for distal femoral physeal bar resection with computed tomography-assisted navigation: a case report. [PDF]

J Surg Case Rep
Masada Y, Tetsunaga T, Yamada K, Inoue T, Okuda R, Yamamoto T, Matsumoto S, Tetsunaga T, Yokoyama Y, Okazaki Y, Ozaki T.   +10 more
europepmc   +1 more source

ASGE guideline for endoscopic full-thickness resection and submucosal tunnel endoscopic resection

VideoGIE, 2019
Harry R. Aslanian, A. Sethi, M. Bhutani, A. Goodman, K. Krishnan, D. Lichtenstein, Joshua E. Melson, U. Navaneethan, R. Pannala, M. Parsi, Allison R. Schulman, Shelby Sullivan, Nirav C. Thosani, G. Trikudanathan, A. Trindade, R. Watson, J. Maple   +16 more
semanticscholar   +1 more source

Tissue‐Resident Macrophage‐Derived E3 Ligase SMURF2 Restricts Autoimmune Inflammation by Mediating the Degradation of p‐TBK1

Advanced Science, EarlyView.
Dysregulated Tissue resident macrophage (TRMs) link to autoimmune inflammation. SMURF2 mediates Lys‐27 (K27)‐linked ubiquitination of p‐TBK1 and its degradation, which inhibits CSF1R signaling‐triggered TRM proliferation, thereby restraining the autoimmune inflammation.
Xiang An, Jun Li, Lingling Wang, Chengyuan Li, Zhenpeng Jin, Yushi Yao, Minmin Jiang, Wenlong Lin, Xiaojian Wang   +8 more
wiley   +1 more source

Tricuspid valve papillary fibroelastoma in an adult patient: a case report and review of literature. [PDF]

J Cardiothorac Surg
Ji Z, Yu C, Musha K, Lin L, Saimi B, Abudurexiti A, Huang H, Shen Z.   +7 more
europepmc   +1 more source

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source