Results 241 to 250 of about 1,479,927 (349)

Surgical therapy of conservatively exhausted rhizarthrosis - total joint replacement or resection arthroplasty? A systematic review. [PDF]

Arch Orthop Trauma Surg
Boever J, Unglaub F, Spies CK, Cavalcanti Kußmaul A, Wulf J, Böcker W, Ayache A.   +6 more
europepmc   +1 more source

DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells

Nature, 2018
Y. He, K. Meghani, Marie-christine Caron, Chunyu Yang, Daryl A. Ronato, J. Bian, Anchal Sharma, J. Moore, Joshi Niraj, A. Detappe, John G Doench, G. Legube, D. Root, A. D’Andrea, P. Drané, S. De, P. Konstantinopoulos, J. Masson, Dipanjan Chowdhury   +18 more
semanticscholar   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Endoscopic full-thickness resection of a rectal submucosal tumor with the double-tunnel bridge formation method: a case report. [PDF]

Endoscopy
Toyoshima N, Sekiguchi M, Takamaru H, Kanemitsu Y, Hijioka S, Haga T, Saito Y.   +6 more
europepmc   +1 more source

pH/ROS‐Responsive Injectable Hydrogel Co‐Loaded with B7‐H3 Blocker and NETs Suppressor Boosts OSCC Synergistic Immunotherapy

Advanced Science, EarlyView.
A pH/ROS‐dual‐responsive injectable hydrogel, formed by dynamic boronic ester and Schiff base crosslinking, co‐delivers enoblituzumab (B7‐H3 blocker) and Cl‐amidine (NETs suppressor). Via localized intratumoral delivery, it synergistically reprograms the immunosuppressive tumor microenvironment, overcomes T cell infiltration barriers, restores ...
Huan Li, Yun Li, Yating Hu, Yanbing Yao, Yaodong He, Jing Li, Jiaqi Tang, Zhenyan Zhao, Yan Wang, Yulun He, Xiaolong Zhang, Xinjie Yang, Jianhua Wei   +12 more
wiley   +1 more source

En Bloc Resection and Vascular Reconstruction for Cecal Cancer Involving the Right Common Iliac Artery and Inferior Vena Cava in a Super-Elderly Patient: A Case Report. [PDF]

Surg Case Rep
Kato T, Hirokawa T, Niwamoto R, Nakazawa M, Sakurai D, Kitamura K, Saito T, Miyai H, Kimura M.   +8 more
europepmc   +1 more source

Endoscopic mucosal resection for treatment of early gastric cancer

Gut, 2001
H. Ono, H. Kondo, T. Gotoda, K. Shirao, H. Yamaguchi, D. Saito, K. Hosokawa, T. Shimoda, S. Yoshida   +8 more
semanticscholar   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Case Report: Adjuvant radiation therapy for cardiac intimal sarcoma with long-term disease control. [PDF]

Front Oncol
Rosa A, Roubil JG, Singh R, Fallahi N, Poklepovic A, Weiss E.   +5 more
europepmc   +1 more source