Results 241 to 250 of about 1,230,831 (347)

Lactate Activates the HCAR1/β‐Arrestin2/PP2A Signaling Axis to Mediate STAT1/2 Dephosphorylation and Drive Osteosarcoma Progression

Advanced Science, EarlyView.
In the present study, it is found that in osteosarcoma, lactate‐activated HCAR1 promotes β‐arrestin 2 translocation from cytoplasm to nucleus. In the nucleus, β‐arrestin 2 recruits PP2A to the activated STAT1/2 dimers, mediating STAT1/2 dephosphorylation and inhibiting the transcription of downstream anti‐oncogenes to promote OS progression.
Zhitao Han, Qi Jia, Guangjian Bai, Zhao Li, Jin Zeng, Zhenhua Wang, Jing Zhang, Jiashi Cao, Baoquan Xin, Yonggang Liu, Jingyu Shen, Lining Wang, Xing Huang, Chunlei Zhang, Kai Tong, Fenglei Dai, Yajie Zhang, Weina Zhu, Songyi Cheng, Yuanming Chen, Xinghai Yang, Guanghui Chen, Zhenhua Zhou, Yong Ma, Weibo Liu, Ting Wang, Tielong Liu   +26 more
wiley   +1 more source

The role of subtalar extrarticular screw arthroereisis (SESA) in surgical treatment of tarsal coalitions. [PDF]

J Orthop Traumatol
De Pellegrin M, Marcucci L, Guindani N, Brogioni L, Fracassetti D.   +4 more
europepmc   +1 more source

AORTIC RESECTION AND ANASTOMOSIS INIPUPS STUDIED AFTER REACHING ADULTHOOD

, 1950
James W. Bhooks
openalex   +2 more sources

Spindle-Celled Sarcoma of Rectum: Excision of Rectum, with Preservation of the Sphincter, by Subperiosteal Resection of the Coccyx and Part of the Sacrum [PDF]

, 1898
Thomas Carwardine
openalex   +1 more source

CXCR1 Depletion in Ly6C+ cDC2 Alleviates Acute Lung Injury via Modulation of Th17/Treg Balance

Advanced Science, EarlyView.
Pro‐inflammatory Ly6C⁺ cDC2s are identified as key effector cells mediating Cxcr1 signaling, driving the progression of ALI. Ly6C⁺ cDC2s release high levels of Il‐6 and Il‐1β, inducing Th17 differentiation. Cxcr1 deficiency reduces Il‐6 and Il‐1β production from Ly6C⁺ cDC2s through suppressing MEK1/ERK /NF‐κB signaling, thereby shifts naïve T cells ...
Shenghui Li, Wei Zhuang, Yang Wang, Hao Qin, Xichun Qin, Xianliang Yan, Xuefei Hu, Xiucheng Liu, Chang Chen   +8 more
wiley   +1 more source

Lung Resection for Chronic Pulmonary Aspergillosis With an Infected Bulla. [PDF]

Clin Case Rep
Tamagawa K, Mori S, Suyama Y, Odaka M, Toya N, Ohtsuka T.   +5 more
europepmc   +1 more source

The Distal and Proximal Margin of Resection in Carcinoma of the Pelvic Colon and Rectum*

, 1955
Joel W. Baker, Lester H. Margetts, Robert P. Schutt   +2 more
openalex   +2 more sources

Extirpation eines von der Schädelbasis ausgehenden Angiomyxofibromes des Nasenrachenraumes mittelst temporärer Resection des harten Gaumens (Chalot) [PDF]

, 1897
Habs
openalex   +1 more source

Sono‐Controllable Janus Hydrogel Platform for Sequential Tumor Eradication and Bone Regeneration in Metastatic Breast Cancer

Advanced Science, EarlyView.
Sequential tumor eradication and bone regeneration remain a significant challenge for patients with breast cancer bone metastases. This study develops a novel Janus hydrogel platform, which can achieve tumor elimination and bone repair under the action of different ultrasound frequencies.
Yitong Li, Yunyun Liu, Chuyun Lou, Xuejun Chen, Ying Zhang, Hui Shi, Jiayi Qiu, Shen Zhang, Taixia Wang, Xiaowei Wang, Haohao Yin, Huixiong Xu, Yifeng Zhang   +12 more
wiley   +1 more source

Multiple brain metastases: resection with IORT versus adjuvant radiotherapy and concurrent irradiation of unresected lesions. [PDF]

Radiat Oncol
Wieger G, Godó Jiménez À, Brehmer S, Etminan N, Stieler F, Giordano FA, Ruder AM.   +6 more
europepmc   +1 more source