Results 331 to 340 of about 1,823,507 (396)

EM2, a Natural Product MST1/2 Kinase Activator, Suppresses Non‐Small Cell Lung Cancer via Hippo Pathway Activation

Advanced Science, EarlyView.
EM2 directly binds to and activates MST1/2, enhancing their kinase activity and sequentially promoting LATS phosphorylation, which increases YAP phosphorylation. Consequently, YAP nuclear translocation is suppressed, leading to reduced transcription of downstream targets CTGF and CYR61, ultimately exerting a robust inhibitory effect on NSCLC cell ...
Siyu Yang, Huayan Xie, Qiang Lin, Liujin Zhou, Junxi Liu, Zekai Fang, Ziling Tang, Ruijie Yuan, Jinxuan Su, Sijia Li, Wenlin Wang, Mingyu Pan, Hao Wang, Xiaoyong Dai, Guocai Wang, Yubo Zhang   +15 more
wiley   +1 more source

Treatment of initially unresectable local advanced pancreatic adenocarcinoma with FOLFIRINOX: A prospective study YCOG1403 (C-FLAP study). [PDF]

Sci Rep
Kobayashi N, Yabushita Y, Mori R, Takahashi T, Miyake K, Sawada Y, Homma Y, Matsuyama R, Okubo N, Katsuta E, Kubota K, Yamanaka S, Ichikawa Y, Endo I.   +13 more
europepmc   +1 more source

Targeting NRP1 in Endothelial Cells Facilitates the Normalization of Scar Vessels and Prevents Fibrotic Scarring

Advanced Science, EarlyView.
Scars exhibit vascular abnormal alterations, including upregulated NRP1 expression in endothelial cells, increased vascular density and branching, compromised vessel wall integrity, and incomplete pericyte coverage. Therapeutic targeting of NRP1 through hydrogel spray delivery offers a promising approach to normalize aberrant vasculature and prevent ...
Yu Wang, Xin Zhou, Min Liu, Meimei Huang, Peirong Chen, Xinying Li, Fangchao Xue, Wenyan Zhao, Di Liu, Lang Li, Yuangang Lu, Wen Zeng   +11 more
wiley   +1 more source

Endoscopic closure of a refractory post-surgical pouch by mucosal resection and suturing. [PDF]

Endoscopy
Sais A, Rivory J, Rostain F, Lupu A, Monneuse O, Grimaldi J, Pioche M.   +6 more
europepmc   +1 more source

Identification of TPRA1 as a Novel Receptor and Predictive Biomarker for Oncolytic Virus M1

Advanced Science, EarlyView.
This study identifies transmembrane protein adipocyte‐associated 1 (TPRA1) as a novel receptor for oncolytic virus M1 (OVM). TPRA1's ectodomain binds OVM particles, while its intracellular domain facilitates virus internalization, promoting efficient viral entry.
Linyi Hu, Guigen Zhang, Yuan Lin, Shiming Yi, Jingyu Yang, Xueying Lin, Deli Song, Zhiheng Liu, Jiayu Zhang, Ying Zeng, Shanyu Huang, Zhen Fan, Jifu Zhang, Ying Liu, Cheng Hu, Wenbo Zhu, Wei Yin, Jun Hu, Guangmei Yan, Jing Cai, Jiankai Liang   +20 more
wiley   +1 more source

TRANSURETHRAL RESECTION

Annals of Surgery, 1936
openaire   +3 more sources

Endoscopic resection of colitis-associated neoplasia: A scoping review. [PDF]

World J Gastrointest Endosc
Pal P, Kata P, Nabi Z, Ramchandani M, Gupta R, Tandan M, Duvvur NR.   +6 more
europepmc   +1 more source

Primary umbilical malignant melanoma requiring full-thickness abdominal wall resection and reconstruction with autologous fascia lata: a case report. [PDF]

Case Reports Plast Surg Hand Surg
Kurokawa Y, Sowa Y, Kado S, Kimura Y, Maekawa T, Komine M, Yoshimura K.   +6 more
europepmc   +1 more source

Long-term follow-up after en bloc resection of the distal radius with reconstruction using ulnar translocation. [PDF]

Case Reports Plast Surg Hand Surg
Ogawa Y, Aiba H, Kawaguchi Y, Yamada S, Kimura H, Hattori Y, Yamaguchi M, Murakami H, Okamoto H.   +8 more
europepmc   +1 more source