Results 111 to 120 of about 17,351 (228)

Identification of relevant environmental descriptors [PDF]

open access: yes, 2018
Based on previous experiences and a literature review the most relevant environmental descriptors were selected and tested by means of field experiments.
Lantinga, Egbert
core  

Formation of Condition‐Dependent Alpha‐Synuclein Fibril Strain in Artificial Cerebrospinal Fluid

open access: yesAdvanced Science, Volume 13, Issue 7, 3 February 2026.
α‐synuclein aggregation in artificial cerebrospinal fluid (aCSF) leads to a distinct conformation with an electron density pocket motif found in aggregates from PD and MSA patients. Such fibrils has low stability outside the reaction conditions, hinting about the influence of cerebrospinal fluid components not only on the formation, but also on the ...
Rūta Sniečkutė   +7 more
wiley   +1 more source

Controlling broad-leaved dock (Rumex obtusifolius) in grass clover mixtures [PDF]

open access: yes, 2006
This article describes three experiments on the control of broad-leaved dock. Experiment 1: Dock seeds were ensiled in grass silages of different dry matter percentages; 23, 34 and 60% respectively.
Fehér, L.   +4 more
core  

Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways

open access: yesAdvanced Science, Volume 13, Issue 7, 3 February 2026.
In this article, Shuai and colleagues found that depletion of Sorcs3 could activate totipotency in mESCs, promising bidirectional differentiation potential to embryonic and extraembryonic lineages. The underlying mechanism might be activation of Tfap2c and repression of TGF‐β, PI3K‐AKT, and lysosome pathways.
Wenhao Zhang   +12 more
wiley   +1 more source

Managing the conversion process successfully [PDF]

open access: yes, 2008
The increase in numbers of farmers considering organic farming as a viable option will lead to an increase in the number of conversion plans to be prepared in the near future.
Barry, Pat, Swan , Brendan
core  

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

open access: yesAdvanced Science, Volume 13, Issue 9, 13 February 2026.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang   +15 more
wiley   +1 more source

Promoting Autophagy Mitigates Stress‐Induced Remodeling in Patient iPSC‐CMs with the Phospholamban R9C Mutation

open access: yesAdvanced Science, Volume 13, Issue 7, 3 February 2026.
The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu   +10 more
wiley   +1 more source

Cadherin‐26 Facilitates Transepithelial Migration of Eosinophils in Eosinophilic Chronic Rhinosinusitis

open access: yesInternational Forum of Allergy &Rhinology, Volume 16, Issue 2, Page 138-151, February 2026.
ABSTRACT Background Eosinophilic chronic rhinosinusitis with nasal polyps (eCRSwNP) is characterized by persistent sinonasal inflammation and marked eosinophilic infiltration. Although the relationship between eosinophils and NP formation has been extensively studied, the mechanisms governing eosinophil transepithelial migration into the nasal mucosa ...
Yeong‐In Jo   +7 more
wiley   +1 more source

Generation and characterization of iPSC‐derived microglia for in vitro modeling of stimuli‐specific neuroimmune responses

open access: yesAlzheimer's &Dementia, Volume 22, Issue 2, February 2026.
Abstract INTRODUCTION Microglia are macrophage‐like brain resident immune cells known to express numerous Alzheimer's disease risk genes. Here we generated a human induced pluripotent stem cell (iPSC) derived microglia cell culture model for use in neuroimmune modeling and therapeutic testing.
Angela K. Haskell   +16 more
wiley   +1 more source

Refertilization of rose clover: Carryover effects of superphosphate applied in one treatment compared with results from annual applications of same rates

open access: yesCalifornia Agriculture, 1957
The first trials of rose clover in California were made in 1944 as part of Research Project 1194B. Rose clover, an annual reseeding legume, is well adapted to soils low in phosphate or sulfur and on which bur clover scarcely exists.
W Martin, W Williams, W Johnson
doaj  

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