Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Modern Application of the Roman Institution of fiducia cum creditore contracta [PDF]
This is a preprint of a piece that appeared in Letitia Vacca, ed., La Garanzia nella prospettiva storico-comparatisca (Torino, 2003), pp. 327-44.The author illustrates the modern application of the Roman fiducia cum creditore contracta by reference to ...
Merwe, Cornelius van der
core
This study underscores the significant influence of frailty and vitality on the subjective health experience of older cancer survivors with acceptance and control emerging as salient mediators. These findings affirm the conceptual and empirical robustness of the model highlighting its potential utility in shaping future interventions for older cancer ...
Damien S. E. Broekharst +4 more
wiley +1 more source
Exercising Sovereignty and Expanding Economic Opportunity Through Tribal Land Management [PDF]
While the United States faces one of the most significant housing crises in the nation's history, many forget that Indian housing has been in crisis for generations.
Karen Edwards +2 more
core
Objective The purpose was to evaluate a biomarker score consisting of MUC5B rs35705950 promoter variant, plasma matrix metalloproteinase (MMP)‐7, and serum anti‐malondialdehyde‐acetaldehyde (anti‐MAA) antibody for RA‐associated interstitial lung disease risk stratification. Methods Using a multicenter cohort of US veterans with RA, we performed a cross‐
Kelsey Coziahr +16 more
wiley +1 more source
Final sitewide environmental assessment for preparation for transfer of ownership of Naval Petroleum Reserve No. 3 (NPR-3), Natrona County, Wyoming [PDF]
The Secretary of Energy is authorized to produce the Naval Petroleum Reserves No. 3 (NPR-3) at its maximum efficient rate (MER) consistent with sound engineering practices, for a period extending to April 5, 2000 subject to extension. Production at NPR-3 peaked in 1981 and has declined since until it has become a mature stripper field, with the average
openaire +2 more sources
ANCSA Corporation Lands and the Dependent Indian Community Category of Indian Country [PDF]
The demand for increased efficiency and patient-centered care has been influencing the development of healthcare in Sweden, and information technology has an important role in that process.
Holmlund, Jeanette, Schimmer, Robyn
core +1 more source
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana +2 more
wiley +1 more source
Sitewide environmental assessment EA-1236 for preparation for transfer of ownership of Naval Petroleum Reserve No. 3 (NPR-3), Natrona County, Wyoming [PDF]
The Proposed Action includes the following principal elements: (1) The accelerated plugging and abandoning of uneconomic wells over the next six years. Uneconomic wells are operating wells which can no longer cover their direct and indirect costs.
openaire +2 more sources
Quantum Emitters in Hexagonal Boron Nitride: Principles, Engineering and Applications
Quantum emitters in hexagonal boron nitride have emerged as a promising candidate for quantum information science. This review examines the fundamentals of these quantum emitters, including their level structures, defect engineering, and their possible chemical structures.
Thi Ngoc Anh Mai +8 more
wiley +1 more source

