Results 51 to 60 of about 2,351,335 (294)

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Flow regime transformation and reservoir architecture difference of lacustrine gravity flows controlled by a slope break zone： A case study from Moxizhuang area， Junggar Basin

Youqi dizhi yu caishoulu
The second Member of the lower Jurassic Sangonghe Formation in the deep Moxizhuang-Yongjin area， the center of the Junggar Basin， has long been interpreted as a braided river delta depositional system.
TAN Xingyu
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Advanced Seismic Sedimentology Techniques for Characterizing Shallow-Water Fan Deltas: Reservoir Architecture and Sedimentary Evolution of the Upper Karamay Formation, Bai21 Area, NW Junggar Basin, China

Applied Sciences
Various glutenite reservoirs, developed by fans, can be found in the Junggar Basin. Among these, there are different interpretations of the glutenite reservoirs formed by shallow-water fan deltas in the Triassic system in the northwestern margin of the ...
Derong Huang, Xinmin Song, Youjing Wang, Guosheng Qin   +3 more
doaj   +1 more source

Research on meandering river reservoir deposition architecture and 3D modeling of the Gudao Oil field in the Bohai Bay Basin

Journal of Petroleum Exploration and Production Technology, 2017
The distribution of remaining oil is controlled by internal sand body heterogeneity in the middle and late stages of oil field development. Reservoir architecture analysis has been conducted in the third sand group in the Guantao Formation of the Gudao ...
Junwei Zhao, Huaimin Xu, Gongyang Chen, Cui He, Dali Yue, Shenghe Wu, Lifeng Wen   +6 more
doaj   +1 more source

Air‐Pressure–Actuated Vibroacoustic Metamaterial With Tunable Bandgap: Design, Modeling, and Characterization

Advanced Engineering Materials, EarlyView.
This article presents the design, modeling, and characterization of air‐pressure–actuated programmable vibroacoustic metamaterials (PVAMM). The study focuses on leveraging air pressure to dynamically tune resonance frequencies for effective noise attenuation.
William Kaal, Michael M. Becker, Sarah C. L. Fischer   +2 more
wiley   +1 more source

Distribution of remaining oil based on fine 3-D geological modelling and numerical reservoir simulation: a case of the northern block in Xingshugang Oilfield, China

Journal of Petroleum Exploration and Production Technology, 2017
As the Xingshugang Oilfield is in the late stage of development, a conventional geological model could not meet the needs of further enhancing oil recovery, and the establishment of a fine 3-D geological model, namely the 3-D reservoir architecture model,
Weiqiang Li, Longxin Mu, Taiju Yin, Lun Zhao, Aiwen Zhao, Pengfei Xie, Feng Li, Lei Huang   +7 more
doaj   +1 more source