Results 41 to 50 of about 324,120 (300)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Reservoir characterization of Pennsylvanian sandstone reservoirs [PDF]

open access: yes, 1991
The overall objectives of this work are: (i) to investigate the importance of various qualities and quantities of data on the optimization of water flooding performance; and (ii) to study the application of newly developed, geostatistical techniques to analyze available production data to predict future prospects of infill drilling.
openaire   +4 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Integrated Analysis of Pressure Transient Tests in the Gulf of Mexico [PDF]

open access: yes, 2011
Imperial Users ...
De Caso, Hernan, De Caso, Hernan
core  

Changes in hydrodynamic, structural and geochemical properties in carbonate rock samples due to reactive transport [PDF]

open access: yes, 2017
Reactive transport plays an important role in the development of a wide range of both anthropic and natural processes affecting geological media. To predict the consequences of reactive transport processes on structural and hydrodynamic properties of a ...
Carrera Ramírez, Jesús   +2 more
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Key technologies for the fluvial reservoir characterization of marginal oil fields

open access: yesPetroleum Exploration and Development, 2012
Fluvial reservoirs of the lower member of the Neogene Minghuazhen Formation in Q33-1 Oilfield, Bohai Bay Basin, are studied as examples to determine the distribution and characteristics of marginal reservoirs and develop offshore marginal oilfields ...
Hui WANG   +4 more
doaj   +1 more source

Fine Scale Simulation of Fractured Reservoirs: Applications and Comparison [PDF]

open access: yes, 2014
Imperial Users ...
Vijayakumar, Akash, Vijayakumar, Akash
core  

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

open access: yesFEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

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