Results 41 to 50 of about 2,485,333 (305)

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Key technologies for the fluvial reservoir characterization of marginal oil fields

open access: yesPetroleum Exploration and Development, 2012
Fluvial reservoirs of the lower member of the Neogene Minghuazhen Formation in Q33-1 Oilfield, Bohai Bay Basin, are studied as examples to determine the distribution and characteristics of marginal reservoirs and develop offshore marginal oilfields ...
Hui WANG   +4 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Pore structure characterization of low permeability rocks [PDF]

open access: yes, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Ciência e Engenharia de Materiais, Florianópolis, 2014.Hoje as pesquisas em rochas de baixa permeabilidade (grande tendência no mundo e em breve ...
Schmitt, Mayka
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Improved reservoir characterization of thin beds by advanced deep learning approach

open access: yesApplied Computing and Geosciences
Targeting reservoirs below seismic resolution presents a major challenge in reservoir characterization. High-resolution seismic data is critical for imaging the thin gas-bearing Khadro sand facies in several fields within the Lower Indus Basin (LIB).
Umar Manzoor   +3 more
doaj   +1 more source

Methodological approaches to determining the marine radiocarbon reservoir effect [PDF]

open access: yes, 2005
The marine radiocarbon reservoir effect is an offset in 14C age between contemporaneous organisms from the terrestrial environment and organisms that derive their carbon from the marine environment.
Dugmore, A., Cook, G.T., Ascough, P.L.
core   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Factors Controlling Differences in Morphology and Fractal Characteristics of Organic Pores of Longmaxi Shale in Southern Sichuan Basin, China

open access: yesFractal and Fractional
Shale gas is a prospective cleaner energy resource and the exploration and development of shale gas has made breakthroughs in many countries. Structure deformation is one of the main controlling factors of shale gas accumulation and enrichment in complex
Yuanlin Wang   +6 more
doaj   +1 more source

Filtering Strategies for Deformation-Rate Distributed Acoustic Sensing

open access: yesSensors, 2022
Deformation-rate distributed acoustic sensing (DAS), made available by the unique designs of certain interrogator units, acquires seismic data that are theoretically equivalent to the along-fiber particle velocity motion recorded by geophones for ...
Jihyun Yang, Jeffrey Shragge, Ge Jin
doaj   +1 more source

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