Results 221 to 230 of about 859,026 (323)

GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh   +8 more
wiley   +1 more source

Active Force Dynamics in Red Blood Cells Under Non‐Invasive Optical Tweezers

open access: yesAdvanced Science, EarlyView.
A non‐invasive method combines low‐power optical tweezers with high‐speed microscopy to simultaneously monitor local membrane forces and displacements in single human red blood cells. This dual‐channel approach reveals a mechano‐dynamic signature that correlates the cell's metabolic state with its mechanical activity. This energetic framework serves as
Arnau Dorn   +5 more
wiley   +1 more source

Hydrothermal Synthesis of γ‑Al<sub>2</sub>O<sub>3</sub> Nanofluids for Enhanced Oil Recovery: Characterization and Coreflooding Evaluation. [PDF]

open access: yesACS Omega
da Rocha CLO   +6 more
europepmc   +1 more source

Modulating Integrin and Growth Factor Signaling With Peptides: Strategies to Synergistically Enhance Bone Tissue Regeneration

open access: yesAdvanced Science, EarlyView.
It has been demonstrated that, in the bone extracellular matrix (ECM), integrins and growth factor receptors (GFRs) engage in synergistic signaling to guide bone healing and regeneration. This review provides a comprehensive overview of current strategies using ECM‐derived peptides to recreate the cellular microenvironment and harness synergistic ...
Lluís Oliver‐Cervelló   +2 more
wiley   +1 more source

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

open access: yesAdvanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira   +18 more
wiley   +1 more source

PRDM1+ Malignant Cells Mediate an Immunosuppressive Landscape and Resistance to Neoadjuvant Chemoradiotherapy and Immunotherapy in Esophageal Squamous Cell Carcinoma

open access: yesAdvanced Science, EarlyView.
Integrated scRNA‐seq, scTCR‐seq analysis, and functional assays identify PRDM1+ malignant epithelial cells with hyper lipid peroxidation characteristics that demonstrate reduced responsiveness to the nICRT treatment. Principal factor PRDM1 activates cysteine metabolism genes to modulate lipid peroxidation (an intrinsic cellular pathway related to ...
Dijian Shen   +12 more
wiley   +1 more source

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