Results 41 to 50 of about 1,006,610 (297)

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

FUNDAMENTAL INVESTIGATION OF PRE-EXISTING FRACTURE SLIP AND PROPAGATION IN RESERVOIR STIMULATION [PDF]

, 2019
The deformation behavior and transport properties of subsurface reservoir rock masses are highly influenced by the existence of natural fractures. Shear reactivation of pre-existing fractures by pressurized fluid injection has been recognized as an ...
Ye, Zhi
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

New research progress of Jurassic tight oil in central Sichuan Basin, SW China

Petroleum Exploration and Development, 2016
The resource potential, “fractured” reservoir, reservoir type and stimulation technology of Jurassic tight oil in central Sichuan basin were investigated.
Yueming YANG, Jiajing YANG, Guang YANG, Shizhen TAO, Chao NI, Bin ZHANG, Xiaodong HE, Jianping LIN, Dong HUANG, Min LIU, Juan ZOU   +10 more
doaj   +1 more source

Heat extraction efficiency in deep geothermal energy mining and implications for EGS-E

工程科学学报, 2022
Geothermal energy has recently attracted substantial attention due to its abundant reserve, cleanness, and sustainability. Geothermal reservoirs can be stimulated via different approaches/techniques that lead to different heat extraction efficiencies and
Ying-chun LI, Wen-ming SUN, Fang-chao KANG, Chun-an TANG   +3 more
doaj   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Application of improved data-driven diagnostics workflow based on coupled hydro-mechanical model for stimulation candidate selection in a complex carbonate reservoir

SN Applied Sciences, 2021
The focus of the present paper is on utilizing a comprehensive diagnostics workflow that combines coupled hydro-mechanical modeling with production data-driven diagnostics for optimization of stimulation candidate selection process.
Seyedeh Hosna Talebian, Mohammad Enayati Najafabadi, Ahmad Fahimifar   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Flow assurance study based on hydrate deposition modeling

Frontiers in Energy Research
During throttling and pressure reduction, hydrates can form due to changes in pipeline pressure, particularly in natural gas with high water content.
Junliang Li, Junliang Li, Meng Cai, Meng Cai, Na Wei   +4 more
doaj   +1 more source