Results 71 to 80 of about 121,898 (285)

NATIONAL STATUSES GRANTED FOR PROTECTION REASONS IN IRELAND. ESRI RESEARCH SERIES NUMBER 96 January 2020 [PDF]

, 2020
This study examines the national statuses that may be granted for protection reasons in Ireland. The report focuses on national statuses with a sole basis in Irish domestic law and policy and does not examine in detail EU-harmonised statuses.
Brazil, Patricia, Groarke, Sarah
core  

KDM4A Erases the H3R17me2a Mark, Facilitating Chromosome Condensation

Advanced Science, EarlyView.
This study reveals a reversible histone modification switch governing chromosome condensation during mitosis. PKCα‐activated KDM4A removes H3R17me2a, permitting Suv39h1‐driven H3K9me3 deposition. This epigenetic transition recruits the chromosomal passenger complex and triggers Aurora B‐dependent H3S10 phosphorylation, coordinating chromatin remodeling
Yena Cho, Jee Won Hwang, Gyu Hwan Hyun, Sangkyu Lee, Dae‐Geun Song, Su‐Nam Kim, Yong Kee Kim   +6 more
wiley   +1 more source

Climate Change Adaptation and Mitigation: Implications for land acquisition and population relocation [PDF]

In response to the challenge of climate change, governments of developing countries are evolving adaptation and mitigation programmes for which they are seeking international financing.
Foresight Programme, UK Government, McDowell, C. A.   +1 more
core  

Material‐Induced Nuclear Deformation Controls Chromatin Architecture in Adipose Stem Cells

Advanced Science, EarlyView.
Tuning cell and cytoskeleton mechanics modulated nuclear shape and heterochromatin organization in ASCs. Distinct cytoskeletal architectures induced nuclear morphologies from oblate to prolate ellipsoids. Large elongated cells with a structured actin cap exhibited high nuclear strain, driving nuclear envelope deformation and heterochromatin ...
Carlo F. Natale, Luca Messina, Valeria Panzetta, Stefania Saporito, Costantino Menna, Maurizio Ventre, Paolo A. Netti   +6 more
wiley   +1 more source

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

Advanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin, Giada Vanni, Veronica Torresan, Margherita Pelosin, Rebecca Busetto, Anna Citron, Ambela Suli, Paolo Contessotto, Carlo Albanese, Francesca Zanconato, Tito Panciera, Stefano Piccolo, Giovanna Brusatin   +12 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Interorganizational Decision-Making in Norwegian Refugee Resettlement

Nordisk Välfärdsforskning
Although the literature on resettlement – the movement of refugees from their first country of asylum to a third country that can offer permanent residency and protection – is growing, we still know relatively little about how categories and criteria for
Ragna Lillevik, Nerina Weiss, Ingunn Bjørkhaug   +2 more
doaj   +1 more source

Barriers and Contradictions in the Resettlement of Single Homeless People [PDF]

, 2008
Research in one local authority area suggests that a number of social policy difficulties and contradictions need to be resolved if single homeless people are to be resettled effectively.
Andrea Willett, Ellison, Grant, Guy Peters, Jamie Harding, Lewis, Lomax, MacGregor, Malpass, McNaughton, Randall, Randall, Rosengard, Seal   +13 more
core   +1 more source

Activated Platelet–Released Heat Shock Protein 90α Triggers Autophagy‐Dependent Neutrophil Extracellular Trap Formation and Amplifies Sepsis

Advanced Science, EarlyView.
HSP90α is significantly upregulated in platelets from sepsis patients, with its origin from megakaryocyte‐derived trafficking. Furthermore, activated platelets secrete HSP90α into the extracellular space in both free and exosome‐associated forms. Finally, extracellular HSP90α directly engages TLR4 on neutrophils to induce autophagy, leading to NET ...
Chengbo Wang, Maodong Leng, Chenchen Sun, Jingyu Cao, Linfei Li, Yangyang Jia, Yongshuai Han, Yuchun Liu, Yaodong Zhang, Chenglong Zhang, Yingli Men, Ningyuan Liu, Yibing Cheng, Yixia Zhang, Ya Li, Zhenlong Li, Lidan Cui, Xiangzhan Zhu   +17 more
wiley   +1 more source

Does disaster resettlement reshape household livelihood adaptive capacity in rural China?

Frontiers in Sustainable Food Systems
To bolster ecological conservation efforts and foster human well-being, the Chinese government has implemented the disaster resettlement program. Rural households encounter various environmental and social challenges regarding disaster resettlement.
Tiejun Zhao, Xinyu Wu, Yuan Cheng, Wei Liu   +3 more
doaj   +1 more source