Results 71 to 80 of about 2,209,671 (402)

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Probability distribution of residence-times of grains in sandpile models [PDF]

open access: yes, 2004
We show that the probability distribution of the residence-times of sand grains in sandpile models, in the scaling limit, can be expressed in terms of the survival probability of a single diffusing particle in a medium with absorbing boundaries and space-
Ali A A   +11 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Hematopoietic (stem) cells—The elixir of life?

open access: yesFEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo   +4 more
wiley   +1 more source

Exploring source water mixing and transient residence time distributions of outflow and evapotranspiration with an integrated hydrologic model and Lagrangian particle tracking approach

open access: yesEcohydrology, 2018
Understanding the time water takes as it moves from rain or snowmelt through the terrestrial system to arrive as stream discharge, or evapotranspiration (ET) is an important hydrologic quantity. We develop a Lagrangian particle tracking method to capture
R. Maxwell   +3 more
semanticscholar   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Halogen-aromatic π interactions modulate inhibitor residence time

open access: yesbioRxiv, 2018
Prolonged drug residence times may result in longer lasting drug efficacy, improved pharmacodynamic properties and “kinetic selectivity” over off-targets with fast drug dissociation rates.
C. Heroven   +8 more
semanticscholar   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

FINANCIAL LITERACY LEVEL OF YOUNG ENTREPRENEURS IN THE PRIVATE UNIVERSITY

open access: yesJurnal Aplikasi Manajemen, 2020
This study aims to illustrate how high the level of financial literacy is amongst young entrepreneurs descriptively. Young entrepreneurs are students who have a business project during their studies at the university. The research methodology used in the
Moehamad Yunus Chalidana   +3 more
doaj   +1 more source

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