Results 71 to 80 of about 2,174,784 (403)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

The Suitability of Adaptive Reuse Practices on Historic Residential Buildings to National Memorials [PDF]

Journal of Design and the Built Environment, 2014
In order to prolong the life of the old buildings in the country through building conservation practices, there is a tendency by the government to acquire and reuse Malaysian leadership figures’ residential buildings as memorials.
Nor Syahila Ab Rashid, Nila Inangda Manyam Keumala H. Daud   +1 more
doaj  

Length of Residence in the United States is Associated With a Higher Prevalence of Cardiometabolic Risk Factors in Immigrants: A Contemporary Analysis of the National Health Interview Survey

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2016
Background Cardiometabolic risk (CMR) factors including hypertension, overweight/obesity, diabetes mellitus, and hyperlipidemia are high among United States ethnic minorities, and the immigrant population continues to burgeon.
Y. Commodore‐Mensah, N. Ukonu, Olawunmi Obisesan, J. Aboagye, C. Agyemang, Carolyn M. Reilly, S. Dunbar, I. Okosun   +7 more
semanticscholar   +1 more source

Probability distribution of residence-times of grains in sandpile models [PDF]

, 2004
We show that the probability distribution of the residence-times of sand grains in sandpile models, in the scaling limit, can be expressed in terms of the survival probability of a single diffusing particle in a medium with absorbing boundaries and space-
Ali A A, Bak P, Deepak Dhar, Dickman R, Ivashkevich E V, Jensen H J, Kadanoff L P, Kertesz J, Manna S S, Pradhan P Nagar A, Punyabrata Pradhan, Turcotte D L   +11 more
core   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Exploring source water mixing and transient residence time distributions of outflow and evapotranspiration with an integrated hydrologic model and Lagrangian particle tracking approach

Ecohydrology, 2018
Understanding the time water takes as it moves from rain or snowmelt through the terrestrial system to arrive as stream discharge, or evapotranspiration (ET) is an important hydrologic quantity. We develop a Lagrangian particle tracking method to capture
R. Maxwell, L. Condon, M. Danesh‐Yazdi, L. Bearup   +3 more
semanticscholar   +1 more source

Two phase residence time distribution in a modified twin screw extruder [PDF]

, 1999
Biomass fractionation is performed with a modified Clextral twin-screw extruder used as a thermo-mechano-chemical reactor. This new process is firstly analyzed.
Altamore, C. Gourdon, Colonna, De Choudens, Doehlert, Isobe, Janssen, L. Prat, L. Rigal, N’Diaye, P. Guiraud, Szydlowski, Tayeb, Yeh   +13 more
core   +2 more sources

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source