Quantifying the Impact of Ocrelizumab on Paramagnetic Rim Lesions in Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Paramagnetic rim lesions (PRLs) are a subset of chronic active multiple sclerosis (MS) lesions marked by iron‐laden microglia and macrophages. Ocrelizumab, a monoclonal antibody targeting CD20+ B cells, suppresses acute MS activity, but its effect on PRLs remains unclear. In a longitudinal study of 29 ocrelizumab‐treated patients with at least
Kimberly H. Markowitz +9 more
wiley +1 more source
Revista de Saúde PúblicaOBJETIVO: Descrever o desenho amostral efetuado para estimar a distribuição de população economicamente ativa, apresentando o efeito do desenho encontrado.
Ricardo Cordeiro
doaj
Sexual Assaults in Anchorage [PDF]
, 2009 Originally published in the Alaska Justice Forum 22(4): 2-3 (Winter 2006).This study examined the characteristics of all sexual assaults reported to the Anchorage Police Department from 2000 through 2003.
UAA Justice Center
core
Raising Awareness about Water Issues: The Role of Water Symbolism and Proverbs
, 2013 Sustainable water management is one of the global grand challenges of our time. Tackling this challenge through corrective actions would require the participation of the general public, a public with sound awareness of the challenge and commitment.
Araya, Yoseph Negusse, Sindik, Joško
core +1 more source
A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp +4 more
wiley +1 more source
Relationship between residence characteristics and polycyclic aromatic hydrocarbon exposure in housewives: second Korean National Environmental Health Survey (2012-2014). [PDF]
Ann Occup Environ Med, 2018 Park HG +6 more
europepmc +1 more source
Individual Attitudes Towards Others, Misanthropy Analysis in a Cross-Country Perspective [PDF]
In general, misanthropy has been analyzed taking into account residents of one country and just comparing results. Instead of doing that, we employ 2004 International Social Survey Program and analyze its determinants in a cross-country model taking into
Máximo Rossi +2 more
core
Psychological characteristics of medical students and residents
Academic Medicine, 1979 A G, Burstein +3 more
openaire +3 more sources
Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone +8 more
wiley +1 more source