Results 141 to 150 of about 380,166 (260)

Structural basis of the residence time of adenosine A_2A receptor ligands revealed by NMR. [PDF]

Chem Sci
Ueda T, Tsuchida T, Kurita M, Mizumura T, Imai S, Shiraishi Y, Kofuku Y, Miyakawa S, Fukuzawa K, Takeuchi K, Shimada I.   +10 more
europepmc   +1 more source

Unraveling the Mechanism of Epichaperome Modulation by Zelavespib: Biochemical Insights on Target Occupancy and Extended Residence Time at the Site of Action. [PDF]

Biomedicines, 2023
Sharma S, Joshi S, Kalidindi T, Digwal CS, Panchal P, Lee SG, Zanzonico P, Pillarsetty N, Chiosis G.   +8 more
europepmc   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Rational Design of Ligands with Optimized Residence Time. [PDF]

ACS Pharmacol Transl Sci
Carloni P, Rossetti G, Müller CE.
europepmc   +1 more source

Loss of reef roughness increases residence time on an idealized coral reef. [PDF]

Sci Rep, 2022
Lindhart M.
europepmc   +1 more source

Human Pegivirus Encephalitis With Brain Detection and Response to Sofosbuvir Ledipasvir

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Human pegivirus (HPgV‐1) has been associated with severe encephalomyelitis in immunocompromised patients. Its neurological spectrum remains poorly defined. We report a slowly progressive encephalitis in a person living with well‐controlled HIV, characterized by white matter abnormalities and inflammatory cerebrospinal fluid (CSF). HPgV RNA was
Antoine Moulignier, Françoise Heran, Francis Lallemand, Pierre Bourdillon   +3 more
wiley   +1 more source

Residence time in drug discovery: current insights and future perspectives. [PDF]

Pharmacol Rep
Kordylewski SK, Bugno R, Podlewska S.
europepmc   +1 more source

Is developmental synchrony enabled by CTCF residence time? [PDF]

Dev Cell, 2021
Wang HV, Corces VG.
europepmc   +1 more source

Digital Cognitive Phenotyping for Differential Diagnosis and Monitoring in Neurological Conditions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the utility, accessibility, and equivalence to supervised scales of online cognitive assessment in older individuals with cognitive impairment. Methods Patients with Alzheimer's disease (AD, n = 31), idiopathic normal pressure hydrocephalus (iNPH, n = 26), and traumatic brain injury (TBI, n = 23) completed online cognitive ...
Martina Del Giovane, Valentina Giunchiglia, Michael C. B. David, Magdalena A. Kolanko, William R. Trender, Peter J. Hellyer, Harmeena Kaur, David J. Sharp, Christopher Carswell, Paresh A. Malhotra, Adam Hampshire   +10 more
wiley   +1 more source

Lignin Extraction and Condensation as a Function of Temperature, Residence Time, and Solvent System in Flow-through Reactors. [PDF]

ACS Sustain Chem Eng
Brandner DG, Gracia Vitoria J, Kenny JK, Bussard JR, Jang JH, Woodworth SP, Vanbroekhoven K, Román-Leshkov Y, Beckham GT.   +8 more
europepmc   +1 more source