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Advanced Functional Materials, EarlyView.The use of continuous drop‐based force and energy probing methods is introduced to evaluate in situ chemical degradation of super liquid‐repellent surfaces by caustic liquids. By tracking the velocity of rolling drops and energy dissipation of impacting drops, degradation dynamics are resolved under high spatio‐temporal precision. Using this technique,
Parham Koochak +2 more
wiley +1 more source
Cell Surface Thiol Engineering Mechanoregulates Myogenic Differentiation via the FAK–PI3K–AKT Axis
Advanced Healthcare Materials, EarlyView.Schematic diagram illustrating how cell surface modification of skeletal muscle progenitor cells through TCEP treatment reveals enhanced cell adhesion, intracellular tension, and myogenesis at 19.66 kPa stiffness, leading to optimal cell fusion. In contrast, no significant changes are observed in the softer (10.61 kPa) or stiffer (49.4 kPa) matrices ...
Juyeon Kim +10 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.A tunable methacrylated decellularized bone matrix hydrogel (dECM‐MA) is developed to support 3D culture of human osteoblasts. The hydrogel preserves bone‐specific ECM cues and allows precise control over mechanical properties. This system provides a customizable platform for studying osteogenic differentiation and modeling bone tissue environments for
Minne Dekker +5 more
wiley +1 more source
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Partial residence times: determining residence time composition in different subregions
Ocean Dynamics, 2019Residence time (RT) is a diagnosis widely used to quantify the water exchange rate and mass transport timescale in semi-enclosed systems. The RT focuses on only the total time a water parcel spends in a system (i.e., control region). However, for a system that consists of several subregions (e.g., sub-bays or functional zones), the RT will not include ...
Lei Lin, Zhe Liu
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The importance of binding kinetics and drug–target residence time in pharmacology
British Journal of Pharmacology, 2023A dominant assumption in pharmacology throughout the 20th century has been that in vivo target occupancy—and attendant pharmacodynamics—depends on the systemic concentration of drug relative to the equilibrium dissociation constant for the drug–target ...
K. Knockenhauer, R. Copeland
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Evolution of the drug-target residence time model
Expert Opinion on Drug Discovery, 2021Introduction The pharmacological action of a drug is linked to its affinity for a specific molecular target as quantified by in vitro equilibrium measurements.
R. Copeland
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2011
[Extract] The residence time is the characteristic time that a parcel of water will remain within a water body. The quantitative definition of "residence time" varies in the literature (Monsen et al., 2002). Generally, it is implied that a complete exchange of the water does not occur in this time.
Stieglitz, Thomas, Ridd, Peter
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[Extract] The residence time is the characteristic time that a parcel of water will remain within a water body. The quantitative definition of "residence time" varies in the literature (Monsen et al., 2002). Generally, it is implied that a complete exchange of the water does not occur in this time.
Stieglitz, Thomas, Ridd, Peter
openaire +4 more sources
Kinetics of Drug Binding and Residence Time.
Annual review of physical chemistry (Print), 2019The kinetics of drug binding and unbinding is assuming an increasingly crucial role in the long, costly process of bringing a new medicine to patients. For example, the time a drug spends in contact with its biological target is known as residence time ...
Mattia Bernetti +3 more
semanticscholar +1 more source