Results 91 to 100 of about 860,879 (347)

Amyotrophic Lateral Sclerosis Prevalence Projection in 2040: A Less Rare Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To project ALS prevalence across multiple countries through 2040, accounting for both population aging and increased survival. Methods Data from the Piemonte and Valle d'Aosta ALS register (PARALS) was used to estimate the trends in incidence and prevalence from 2005 to 2019. Survival trends over this period were also assessed.
Rosario Vasta, Stefano Callegaro, Antonio Canosa, Umberto Manera, Maurizio Grassano, Francesca Palumbo, Sara Cabras, Enrico Matteoni, Francesca Di Pede, Filippo De Mattei, Salvatore Tafaro, Neil M. Thakur, Ryan Grosenick, Fabiola De Marchi, Letizia Mazzini, Cristina Moglia, Andrea Calvo, Kuldip D. Dave, Adriano Chiò   +18 more
wiley   +1 more source

Semi-markov model of processing requests to the cloud storage

MATEC Web of Conferences, 2017
This paper presents a semi-Markov model as an important part of the computer-aided manufacturing and a modular system of cloud storage, which affects the functioning of the whole process. The residence times of the system in states and the probability of
Zamoryonov Mikhail, Shevchenko Victoria, Vladimirova Elena, Sapozhnikov Nikolay   +3 more
doaj   +1 more source

Portable Low‐Field Magnetic Resonance Imaging in People With Human Immunodeficiency Virus

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aging population of people with HIV (PWH) raises heightened concerns regarding accelerated aging and dementia. Portable, low‐field MRI (LF‐MRI) is an innovative technology that could enhance access and facilitate routine monitoring of PWH.
Annabel Sorby‐Adams, Malachi Keo, Jennifer Guo, Daire Daly, Richard Ahern, Kimon Zachary, Gregory Robbins, Rajesh T. Gandhi, Bragi Sveinsson, Adam de Havenon, Kevin N. Sheth, Otto Rapalino, Juan Eugenio Iglesias Gonzales, W. Taylor Kimberly, Shibani S. Mukerji   +14 more
wiley   +1 more source

Turbulent flow in pulsed extraction columns with internals of discs and rings:Turbulent kinetic energy and its dissipation rate during the pulsation [PDF]

, 2009
Turbulent energy parameters of single-phase pulsed flow in an extraction column with internals of immobile discs and rings (doughnuts) are studied. Simulation results are obtained by resolution of Reynolds equations coupled with k–ɛ model of turbulence ...
Angelov, George, Gourdon, Christophe
core   +1 more source

Residence time distribution in continuous virus filtration

Biotechnology and Bioengineering
Regulatory authorities recommend using residence time distribution (RTD) to address material traceability in continuous manufacturing. Continuous virus filtration is an essential but poorly understood step in biologics manufacturing. Here we describe a model that considers non-ideal mixing and film resistance for RTD prediction in continuous virus ...
Yu‐Cheng Chen, Gabriele Recanati, Fernando De Mathia, Dong‐Qiang Lin, Alois Jungbauer   +4 more
openaire   +2 more sources

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Characterization of the wave bioreactor: residence time distribution [PDF]

, 2010
The high dose requirements of biopharmaceutics have led to the development of mammalian cell culture technologies to increase biomanufacturing capacity. Among them, disposable bioreactors are attracting attention, particularly the Wave bioreactor.
Azeredo, Joana, Costa, A. R., Oliveira, Rosário, Rodrigues, E.   +3 more
core  

Waiting for rare entropic fluctuations

, 2015
Non-equilibrium fluctuations of various stochastic variables, such as work and entropy production, have been widely discussed recently in the context of large deviations, cumulants and fluctuation relations.
Dhar, Abhishek, Saito, Keiji
core   +1 more source

A Nonequilibrium Rate Formula for Collective Motions of Complex Molecular Systems [PDF]

, 2010
We propose a compact reaction rate formula that accounts for a non‐equilibrium distribution of residence times of complex molecules, based on a detailed study of the coarse‐grained phase space of a reaction coordinate.
Koon, Wang Sang, Marsden, Jerrold E., Yanao, Tomohiro   +2 more
core   +1 more source

Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT The practice of neurology requires an understanding of clinical ethics for decision‐making. In multiple sclerosis (MS) care, there are a wide range of ethical considerations that may arise. These involve shared decision‐making around selection of a disease‐modifying therapy (DMT), risks and benefits of well‐studied medications in comparison to
Methma Udawatta, Farrah J. Mateen
wiley   +1 more source