Results 41 to 50 of about 204,706 (259)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and Development of Mathematical Model for Static Mixer [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2016 A numerical model for simulating Residence Time Distribution (RTD) of turbulent flows in helical static mixers is proposed and developed to improve the understanding of static mixers.
Akila Rajamanickam, Krishnaswamy Balu
doaj
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
An attainable region perspective on the role of residence time distribution in ball milling
South African Journal of Chemical Engineering, 2020 The effect of material flow through a ball mill on the efficient production of particles was explored using the attainable region framework. The target efficiency was the production of floatable particles of size between 300 μm and 75 μm upon expending ...
François K. Mulenga
doaj +1 more source
Effect of Scale-Up on Residence Time and Uranium Extraction on Annular Centrifugal Contactors (ACCs)
Separations, 2023 This work reports the effect of scaling up annular centrifugal contactors (ACCs) upon the residence time distribution and the efficiency of extraction of uranium.
Alastair Baker +4 more
doaj +1 more source
Modeling of residence time distribution in regrinding Vertimill
Minerals Engineering, 2013 Abstract The regrinding stage is necessary to achieve the particle size (liberation) for the final upgrade in the cleaning flotation process. At present, vertical stirred mills are increasingly employed at industrial scale. The regrinding process characterization requires mixing regime knowledge along with the mean residence time of the liquid and ...
Yianatos, J. +3 more
openaire +3 more sources
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Experimental simulation of salt transport in hierarchically nested groundwater flow systems
地质科技通报, 2022 Groundwater age and groundwater residence time contain important information about groundwater circulation and evolutionary processes, and have been widely used in the study of groundwater circulation patterns in basins.In this paper, we simulated a ...
Hong Niu +5 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source