Results 41 to 50 of about 202,714 (259)
Design and Development of Mathematical Model for Static Mixer [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2016 A numerical model for simulating Residence Time Distribution (RTD) of turbulent flows in helical static mixers is proposed and developed to improve the understanding of static mixers.
Akila Rajamanickam, Krishnaswamy Balu
doaj
Material Transport Characteristics in Planetary Roller Melt Granulation
Pharmaceutics, 2023 Melt granulation for improving material handling by modifying particle size distribution offers significant advantages compared to the standard methods of dry and wet granulation in dust reduction, obviating a subsequent drying step. Furthermore, current
Tom Lang +3 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
An attainable region perspective on the role of residence time distribution in ball milling
South African Journal of Chemical Engineering, 2020 The effect of material flow through a ball mill on the efficient production of particles was explored using the attainable region framework. The target efficiency was the production of floatable particles of size between 300 μm and 75 μm upon expending ...
François K. Mulenga
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
An improved model of continuous leaching systems using segregation approach [PDF]
International Journal of Mining and Geo-Engineering, 2020 In this study, a simplified dissolution model has been developed to evaluate the performance of continuous leaching reactors. The model considers continuous reduction of the surface area of particles using the distribution of their size and residence ...
Abdolrahim Foroutan +3 more
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Experimental simulation of salt transport in hierarchically nested groundwater flow systems
地质科技通报, 2022 Groundwater age and groundwater residence time contain important information about groundwater circulation and evolutionary processes, and have been widely used in the study of groundwater circulation patterns in basins.In this paper, we simulated a ...
Hong Niu +5 more
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source