Results 81 to 90 of about 215,638 (342)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Catchment travel time distributions and water flow in soils [PDF]

, 2011
Many details about the flow of water in soils in a hillslope are unknowable given current technologies. One way of learning about the bulk effects of water velocity distributions on hillslopes is through the use of tracers.
Russo D, Botter G., Bertuzzo, E., Russo, D., Beven, K.J., Nicotina, L., D. Russo, Beven, K. J., Rinaldo, A, Rinaldo A, Rosso, D., BERTUZZO, ENRICO, FIORI, ALDO, RINALDO, ANDREA, Nicotina L, L. Nicotina, Davies, Jessica, E. Bertuzzo, A. Fiori, Beven KJ, A. Rinaldo, J. Davies, NICOTINA, LUDOVICO, Fiori, A., Beven, Keith, Fiori A, Davies J, G. Botter, Bertuzzo E, BOTTER, GIANLUCA, Davies, J., Rinaldo, A., K. J. Beven, Botter, G.   +33 more
core   +1 more source

Feasibility and Tolerability of Performing Portable MRI for Neurological Disorders in an Outpatient Neurology Clinic: A Prospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Accessing brain magnetic resonance imaging (MRI) can be challenging, especially for underserved patients, which may lead to disparities in neurological diagnosis. Method This mixed‐methods study enrolled adults with one of four neurological disorders: mild cognitive impairment or dementia of the Alzheimer type, multiple sclerosis ...
Maya L. Mastick, Nomin Enkhtsetseg, Joseph Sadok, Matheus Mochetti, Annabel Sorby Adams, Jennifer Guo, Cristina Trapaga Hacker, Isabella Gomez Hjerthen, Seungwon Lee, Siddharth Satish, Andrew S. Ham, Justin Hill, Denis Balaban, Kevin Kyle, Rebecca L. Gillani, Marcelo Matiello, Aleksandar Videnovic, Eric C. Klawiter, W. Taylor Kimberly, Farrah J. Mateen   +19 more
wiley   +1 more source

Residence time distribution of gas flows in microreactors: Measurement and model comparison

, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
Blank, T, Anurjew, E, Leyrer, B, Schygulla, U, Wibel, W, Brandner, JJ, Dittmeyer, R, 3rd Micro and Nano Flows Conference (MNF2011)   +7 more
core  

Functional and Structural Evidence of Neurofluid Circuit Aberrations in Huntington Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Disrupted neurofluid regulation may contribute to neurodegeneration in Huntington disease (HD). Because neurofluid pathways influence waste clearance, inflammation, and the distribution of central nervous system (CNS)–delivered therapeutics, understanding their dysfunction is increasingly important as targeted treatments emerge.
Kilian Hett, Abigail Dubois, Melanie Leguizamon, Alexander Song, Paula Trujillo, Colin D. McKnight, Ciaran M. Considine, Manus J. Donahue, Daniel O. Claassen   +8 more
wiley   +1 more source

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

Residence Time Distribution of Multiple Particles in Four Configurations of Holding Tubes

, 2004
Residence time distributions of multiple particles (as affected by process and system parameters) were investigated during non-Newtonian tube flow. Process parameters included flow rate, particle type, carrier fluid viscosity, and particle concentration.
Tanyel, Zeynep
core  

Residence time distribution in model tubes

, 2021
Cilj ovog rada je odrediti raspodjelu vremena zadržavanja u modelnim cijevima. Eksperiment se provodio injektiranjem dva volumena trasera (1 mL i 0,5 mL) u tri različite cijevi, praznu cijev, cijev ispunjenu kuglicama i spiralnu cijev pri tri različita ...
Blažević, Iva
core   +2 more sources

Residence time distribution in continuous virus filtration

Biotechnology and Bioengineering
Regulatory authorities recommend using residence time distribution (RTD) to address material traceability in continuous manufacturing. Continuous virus filtration is an essential but poorly understood step in biologics manufacturing. Here we describe a model that considers non-ideal mixing and film resistance for RTD prediction in continuous virus ...
Yu‐Cheng Chen, Gabriele Recanati, Fernando De Mathia, Dong‐Qiang Lin, Alois Jungbauer   +4 more
openaire   +2 more sources