Results 191 to 200 of about 9,613 (261)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Computational screening of walnut (Juglans regia) husk metabolites reveals Aesculin as a potential inhibitor of pectate lyase Pel3: Insights from molecular dynamics and τRAMD. [PDF]

Biochem Biophys Rep
Khakpour A, Shadmehri NA, Sedaghati A, Jamshidian H, Ghiabi S, Baziyar P, Heidari-Soureshjani E, Mirahmadi SA.   +7 more
europepmc   +1 more source

Stress‐Induced Activation of Prolactin‐NR4A1‐Midkine Axis Exacerbates Skin Inflammation

Advanced Science, EarlyView.
Chronic psychological stress activates prolactin signaling to reprogram dermal fibroblasts into APCDD1+ inflammatory effectors via NR4A1, driving midkine secretion. This paracrine hub amplifies keratinocyte proliferation and immune recruitment, thus exacerbating skin inflammation.
Zhiguo Li, Huiyi Quan, Wanting Liu, Jiaoling Chen, Mengyang Chu, Xin Tang, Ke Xue, Xuan Liu, Jingyi Ma, Yaxing Bai, Ruina Dong, Bing Li, Junfeng Hao, Wei Guo, Qingyang Li, Erle Dang, Johann E Gudjonsson, Gang Wang, Shuai Shao   +18 more
wiley   +1 more source

Microfluidic engineering of pDNA nanogels in a coaxial flow reactor: process development, optimisation, scalability and <i>in vitro</i> performance. [PDF]

Nanoscale Adv
Patil S, Whiteley Z, Osarfo-Mensah E, Pankajakshan A, Craig DQM, Guldin S, Gurnani P, Gavriilidis A.   +7 more
europepmc   +1 more source

TMEM131‐Mediated Soluble TRAIL Triggered Type II Alveolar Epithelial Cell Senescence in Radiation‐Induced Lung Injury

Advanced Science, EarlyView.
TMEM131 recruits the COPII complex to accelerate TRAIL transportation from endoplasmic reticulum to Golgi apparatus, and promotes soluble TRAIL secretion. TRAIL inhibits mitophagy and induces senescence through DR5 receptor in type II alveolar epithelial cells, ultimately driving radiation‐induced lung injury (RILI) progression.
Linzhi Han, Chunsheng Wang, Xiuli Guo, Yuan Luo, Jianguo Zhang, Fajian He, Zihang Zeng, Jiang Luo, Wen Ouyang, Yan Gong, Conghua Xie   +10 more
wiley   +1 more source

Optimization of Injection-Molded Thermoplastic Microfluidic Chip Design with Numerical Modeling and Two-Photon Polymerization 3D Printing

Mallorie C, Schneeweis B, Pitzek M, Holzner C, Lidl C, de Cleir S, Milanovic N, Foglia D, Krüger T, Carey TR.   +9 more
europepmc   +1 more source

Computational methods for inertial microfluidics: recent advances and future perspectives. [PDF]

Microsyst Nanoeng
Lauricella G, Naderi MM, Owen B, Mostafazadeh N, Zhou J, Peng Z, Papautsky I.   +6 more
europepmc   +1 more source

A Dynamic DNA Nano‐Antioxidant Targeting Galectin‐3 Attenuates Liver Fibrosis via Reducing Macrophage Oxidative Stress

Advanced Science, EarlyView.
This study developed a dynamic DNA nano‐antioxidant (DDN) for Galectin‐3 siRNA delivery, specifically targeting hepatic macrophages to suppress ROS‐driven fibrosis. DDN enhanced hepatic accumulation, restored NRF2 signaling, and attenuated oxidative stress, collagen deposition, and fibrotic progression in a CCl4‐induced cirrhosis model, demonstrating ...
Mengjia Peng, Jianguo Xu, Youjian Hong, Fei Fang, Yan Li, Duo Ci, Bowen Wang   +6 more
wiley   +1 more source

Glymphatic Clearance in the Optic Nerve: A Multidomain Electro-Osmostic Model. [PDF]

Entropy (Basel)
Xiao S, Huang H, Eisenberg R, Song Z, Xu S.   +4 more
europepmc   +1 more source

Advanced Stem Cell Therapy: 3D‐Bioprinted Brain‐Like Transplants for Alzheimer's Disease‐Like Dementia

Advanced Science, EarlyView.
A tri‐component biomimetic bioink(gelatin/alginate/fibrinogen) is developed to protect cells in critical pathological environments in AD. Using this bioink, a 3D‐printed NPC construct optimized for hippocampal transplantation is provided to improve cell retention and differentiation in an AD‐like model. This approach enhances memory recovery and offers
Ke Gai, Yu Song, Dawen Gao, Qingning Nie, Xiao Luo, Caizhe Xu, Changhao Cai, Austin Smith, Xiang Li, Wei Shi, Lei Zhang, Wei Sun, Feng Lin   +12 more
wiley   +1 more source