Results 41 to 50 of about 111,848 (245)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Un monstruo viene a vernos [PDF]

Revista SOCAMPAR, 2020
Varón de 53 años, obeso y exfumador de 20 cig./día, sin otros antecedentes de interés. Acude en numerosas ocasiones a nuestro Servicio de Urgencias por disnea, que comienza con los esfuerzos y se intensifica progresivamente hasta hacerse de reposo. Como
Sajardo Bautista L, Andrés Andrés A, García Martínez G, Cordero Bernabé̗ R, Molina Cano A, Callado Pérez D, Del Valle Apastegui R   +6 more
doaj  

Entre sentido de pertenencia y potencial de desarrollo: la percepción del turismo en los residentes de Zaruma

Revista Eruditus, 2022
El turismo sostenible es un elemento potencial de desarrollo cultural y económico para una ciudad; sin embargo, para poder implementarlo es necesario el involucramiento de los residentes.
Maritza Lisseth Cruz, Lorenzo Bonisoli, Jose Andrés Albarracín   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Fluxo da informação na prática clínica dos médicos residentes: aproximações possíveis com a medicina baseada em evidências [PDF]

, 2008
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Educação, Programa de Pós-Graduação em Ciência da Informação, Florianópolis, 2008Pesquisa que identifica o fluxo da informação na prática clínica do médico residente ...
Savi, Maria Gorete Monteguti, Savi, Maria Gorete M.   +1 more
core  

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Burnout en residentes de enfermería [PDF]

, 2011
Nursing residents may experience physical and emotional exhaustion from the daily life of attending the Program. The aim of this study was to determine the Burnout incidence among Nursing Residents. An investigative, descriptive, analytical, longitudinal-
Alba Lúcia Bottura Leite de Barros, Luiz Antônio Nogueira-Martins, Barros, Alba Lucia Bottura Leite de [UNIFESP], Franco, Gianfábio Pimentel [UNIFESP], Nogueira-Martins, Luiz Antonio [UNIFESP], Sandra Salloum Zeitoun, Barros, Alba Lúcia Bottura Leite de, Gianfábio Pimentel Franco, Zeitoun, Sandra Salloum, Zeitoun, Sandra Salloum [UNIFESP], Nogueira-Martins, Luiz Antônio, Franco, Gianfábio Pimentel   +11 more
core   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source