Results 41 to 50 of about 689,020 (280)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Construction of Evaluation Index System for Suitability of Sunshine and Thermal Environment of Public Activity Space for the Elderly with Young Children

Buildings
With the aging of China’s population and the liberalization of the birth policy, the country’s social population structure has changed, and the public activity spaces of residential areas are expected to meet the new needs created by such change ...
Minmin Yang, Yu Liu
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Friendliness as a systemic characteristic of the residential environment: significance and needs of young families with young children

Векторы благополучия: экономика и социум
Based on surveys of experts and representatives of young families with children, the author has identified the specific requirements for the residential environment.
V.S. Burtseva
doaj   +1 more source

Spatial Underpinnings of Social Inequalities: A Vicious Circles of Segregation Approach

Social Inclusion, 2021
A paradigm shift is taking place in spatial segregation research. At the heart of this shift is the understanding of the connectedness of spatial segregation in different life domains and the availability of new datasets that allow for more detailed ...
Tiit Tammaru, David Knapp, Siiri Silm, Maarten van Ham, Frank Witlox   +4 more
doaj   +1 more source

Uncovering the spatial structure of mobility networks [PDF]

, 2015
The extraction of a clear and simple footprint of the structure of large, weighted and directed networks is a general problem that has many applications.
Barthelemy, Marc, Cantú, Oliva García, Frias-Martinez, Enrique, Herranz, Ricardo, Lenormand, Maxime, Louail, Thomas, Picornell, Miguel, Ramasco, José J.   +7 more
core   +7 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Architectural features of the outdoor spaces of non-gated residential communities for increasing children’s physical activity

Revista INVI
As the health of children is important for the next generation, a lack of physical activity can be considered a critical health challenge. One major factor influencing children's physical activity is the built environment, particularly their home area ...
Saba Hejazi, Minoo Shafaei, Niloufar Malek, Thomas H.-K. Kang, Jin Baek   +4 more
doaj   +1 more source

Long-term exposure to particulate matter and residential greenness in relation to androgen and progesterone levels among rural Chinese adults

Environment International, 2021
Background: Population-based studies on the associations of long-term exposure to particulate matter (PM) with androgen and progesterone are still scant. Residential greenness is benefits health by promoting physical activity, reducing air pollution, and
Dandan Wei, Shanshan Li, Xue Liu, Li Zhang, Pengling Liu, Keliang Fan, Luting Nie, Lulu Wang, Xiaotian Liu, Jian Hou, Wenqian Huo, Songcheng Yu, Linlin Li, Tao Jing, Xing Li, Wenjie Li, Yuming Guo, Chongjian Wang, Zhenxing Mao   +18 more
doaj   +1 more source

Use of Symptomatic Drug Treatment for Fatigue in Multiple Sclerosis and Patterns of Work Loss

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To describe the use of central stimulants and amantadine for fatigue in MS and evaluate a potential association with reduced work loss in people with MS. Methods We conducted a nationwide, matched, register‐based cohort study in Sweden (2006 to 2023) using national registers with prospective data collection.
Simon Englund, Johan Reutfors, Thomas Frisell, Fredrik Piehl   +3 more
wiley   +1 more source