Results 221 to 230 of about 3,372,140 (289)

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

Advanced Science, EarlyView.
The injectable CeTA@GPP hydrogel is administered via intrauterine injection, forming a protective barrier. In the high ROS inflammatory microenvironment of injured endometrium, boronate ester cleavage triggers responsive CeTA release and local enrichment.
Peixian Cheng, Jian Song, Yuxin Li, Ming Chen, Zeshen Liang, Binyao Qiu, Xuemin Liu, Xuetao Shi, Yong Fan   +8 more
wiley   +1 more source

Probabilistic Computing via Gate‐Tunable Random Telegraph Noise

Advanced Science, EarlyView.
Intrinsic random telegraph noise in metal–oxide–semiconductor field‐effect transistors is harnessed to create gate‐tunable probabilistic bits. By modulating carrier‐trapping dynamics, the device produces stochastic binary outputs with a continuous bias‐to‐probability transfer.
Gyungwon Yun, Jin Pyo Kang, Ho‐Sung Lee, Ik‐Hyeon Jeon, Ki‐Ju Park, Won‐Ju Cho, Seung‐heon Chris Baek, Joo‐Hyung Chae, Hamin Park   +8 more
wiley   +1 more source

Chelation‐Driven Dual‐Interface Regulation for Long‐Life Aqueous Zn–I2 Batteries

Advanced Science, EarlyView.
Zn2+–TPEN coordination generates TPEN‐derived coordination species (TCC) that contribute to the regulation of both electrode interfaces. At the Zn anode, it creates an interfacial environment with reduced water accessibility that suppresses HER and corrosion while promoting uniform deposition; at the I2 cathode, it captures polyiodide to inhibit ...
Dong Wook Kim, Seung Hwa Park, Tae Rim Kim, Gun Jang, Jun Su Kim, Myung‐Jun Kwak, Seokhwan Jin, Seongbin Ga, Chihyun Hwang, Ho Seok Park, Youngkwon Kim   +10 more
wiley   +1 more source

Nanocluster‐Assisted OH Ligand Modification Optimizes Activity and Stability of Fe‐N‐C Catalysts

Advanced Science, EarlyView.
A nanocluster‐assisted ligand engineering stabilizes OH‐modified FeN4 active sites through strong electronic coupling between isolated Fe atoms and adjacent nanoclusters. This synergy optimizes oxygen‐intermediate adsorption, lowers ORR energy barriers, and breaks the conventional activity–stability trade‐off, enabling high ORR activity, exceptional ...
Xue Zhao, Junpeng Chen, Shice Wang, Zhao Yu, Jing Wang, Qiuming Peng, Ge Li   +6 more
wiley   +1 more source

Greener Solvents for the Photoisomerization and Catalytic Heat Release of a Norbornadiene‐Based Molecular Solar Thermal Energy Storage System

Advanced Science, EarlyView.
A Molecular Solar Thermal (MOST) system combining a scalable norbornadiene–quadricyclane photoswitch, a biodegradable solvent, propylene carbonate, and noble and first‐row metal catalysts, is presented. Propylene carbonate boosts photoisomerization quantum yield by 25% compared to toluene, prolongs energy storage by an additional 15 days, and enables ...
Lucien Magson, Helen Hölzel, Rebecca J. Salthouse, Liang Fei, Pedro Ferreira, Vitor A. S. Almodovar, Kasper Moth‐Poulsen, Ignacio Funes‐Ardoiz, Diego Sampedro   +8 more
wiley   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

Engineered Transformer Base Editor with Enhanced Editing Efficiency

Advanced Science, EarlyView.
A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen, Letong Liang, Rui Xu, Tianyi Wang, Hongyan Chen, Daru Lu   +5 more
wiley   +1 more source

Targeted Lysosomal Degradation of Extracellular and Membrane Proteins: From Receptor Hijacking to Programmable Endolysosomal Routing

Advanced Science, EarlyView.
Targeted chimeric degraders engage extracellular or membrane proteins and endocytosable cell‐surface receptors, forming ternary complexes that induce receptor‐mediated internalization. Following endocytosis, post‐endocytic sorting—not internalization alone—determines target fate.
Ke Liu, Xiyan Wang, Xiaozhen Liu, Chaoqi He, Da Qian, Xuli Meng, Liquan Zhu   +6 more
wiley   +1 more source

Self‐Propelled HPB@Lip@AB Nanomotors Ameliorate Dry Eye Disease

Advanced Science, EarlyView.
A self‐propelled HPB@Lip@AB nanomotor system is developed for dry eye disease (DED) therapy, facilitating rapid penetration across ocular surface barriers while integrating hydrogen therapy with multi‐enzyme‐like antioxidant activity. The nanoplatform restores mitochondrial function, suppresses oxidative stress, inflammation, and apoptosis, and ...
Jing Li, Xi Wan, Xinru Su, Zechuan Li, Yue Wang, Ying Wang, Ruofei Li, Huangzhao Wei, Jianbin Zhang, Shuai Wang   +9 more
wiley   +1 more source