Results 61 to 70 of about 31,626 (250)

Double Tendoachilles in One Leg [PDF]

Indian Journal of Physical Medicine & Rehabilitation, 2007
Poliomyelitis is still one of the common causes of childhooddisability in a developing country like India. There arethousands of neglected (chronic) cases of post polioresidual paralysis, who are crawling in the villages and areunable to stand and walk ...
Khare R, Agarwal AK
doaj  

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Enteroviruses and Adenoviruses in stool specimens of paralytic children- can they be the cause of paralysis?

Iranian Journal of Microbiology, 2018
Background and Objectives: Acute flaccid paralysis (AFP) is a complicated clinical syndrome with a wide range of potential etiologies. Several infectious agents including different virus families have been isolated from AFP cases.
Maryam Yousefi, Ahmad Nejati, Seyed Mohsen Zahraei, Sussan Mahmoudi, Najmeh Parhizgari, Seyed Mohammad Jazayeri Farsani, Mahmood Mahmoodi, Rakhshandeh Nategh, Shohreh Shahmahmoodi   +8 more
doaj  

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Arthroscopic Ankle Fusion in the Post-Polio Paralytic Foot

Arthroscopy Techniques
Post-polio residual paralysis can lead to severe musculoskeletal issues, including foot deformities and ankle instability, which can progress to end-stage arthritis.
Jimmy Joseph Meleppuram, M.S.Ortho., Ayyappan V. Nair, D.Ortho., D.N.B.Ortho., Hamdi Nizar Ahamed, M.S.Ortho., Nizaj Nasimudeen, D.N.B.Ortho., M.R.C.S., Ananthakrishnan Radhakrishnan, M.B.B.S., Ajayakumar Thankappan, M.S.Ortho., Prince Shanavas Khan, D.Ortho., M.S.Ortho.   +6 more
doaj   +1 more source

Effects of induction of anaesthesia and muscle paralysis on functional residual capacity of the lungs [PDF]

Canadian Anaesthetists’ Society Journal, 1968
A helium dilution method of measuring FRC under conditions of controlled ventilation is described. Using this method the effect on FRC of premedication and of induction of anaesthesia and muscle paralysis has been investigated. No significant change in FRC was found with premedication alone.
openaire   +2 more sources

Endothelial YAP Signaling Promotes Blood‐Spinal Cord Barrier Repair in Mice After Spinal Cord Injury

Advanced Science, EarlyView.
Endothelial YAP is required for blood‐spinal cord barrier repair after spinal cord injury. YAP‐dependent vascular repair is associated with ANGPT1/PI3K/AKT signaling in vivo and may involve endothelial‐pericyte paracrine interactions. By supporting vascular remodeling, tight junction restoration, restored pericyte coverage, and astrocyte‐vascular ...
Jiawei Wang, Yaozhi He, Yanjiao Wang, Jingjing Zhang, Qishun Liang, Mengxian Jia, Yumin Wu, Zongjie Yuan, Ziwei Fan, Yuxuan Li, Huihui Zhang, Qinjiao Fu, Ying Wang, Zhihui Huang, Honglin Teng   +14 more
wiley   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

Prevalence Of Common Neurological Diseases In A Rural Community Of India

Indian Journal of Community Medicine, 1989
To find out the prevalence of clinical diagnosable neurological disorders three important symptoms were used for screening of patients. These were convulsions, paralysis and chronic headache.
Kapoor S.K, Banerjee A.K
doaj