Results 91 to 100 of about 7,181,436 (281)

Sex-Specific Impact of Roxadustat on Residual Kidney Function in Peritoneal Dialysis Patients: A Propensity Score-Weighted Analysis

Kidney Medicine
Rationale & Objective: Roxadustat effectively improves renal anemia, but its impact on residual kidney function (RKF) preservation in continuous ambulatory peritoneal dialysis (CAPD) patients is unclear.
Simin Jiang, Guanji Zhang, Yiping Xu, Yi Li, Guanglan Li, Hongyu Li, Yuchu Liu, Siyuan Li, Jianxiong Lin, Qunying Guo, Xiao Yang, Wei Chen, Haiping Mao, Yating Wang   +13 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Risk factors for loss of residual renal function in children treated with chronic peritoneal dialysis [PDF]

, 2015
Artículo de publicación ISIIn dialyzed patients, preservation of residual renal function is associated with better survival, lower morbidity, and greater quality of life. To analyze the evolution of residual diuresis over time, we prospectively monitored
Flynn, J.T., Hooman, Nakysa, Schaefer, Franz, Van Hoeck, K., Zambrano, P.H., Schaefer, F., van Hoeck, Koen, Munarriz, R.L., Szczepanska, M., Lai, W.-M., Zambrano Ostaíza, Pedro, Ha, I.-S., Klaus, G., Sahpazova, Emilja, Gulati, Ashima, Lai, Wai-Ming, Higuita, Lina M. S., Higuita, L.M.S., Sander, Anja, Gulati, A., Antonio, Zenaida L., Klaus, Günter, Ha, Il-Soo, Antonio, Z.L., Riyami, M.A., Sahpazova, Lja, Hooman, N., Fischbach, M., Sahpazova, E., Hoeck, Koen van, Szczepanska, Maria, Sander, A., Verrina, E., Bilge, Ilmay, Flynn, Joseph T., Yap, H.K., Higuita, Lina, Warady, Bradley A., Klaus, Guenter, Munarriz, Reyner L., Bilge, I., Yap, Hui K., Verrina, Enrico, Warady, B.A., Zambrano, Pedro H., Fischbach, Michel, Riyami, Mohammed A.   +46 more
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Predictors of Faster Decline of Residual Renal Function in Taiwanese Peritoneal Dialysis Patients

, 2011
OBJECTIVE: Loss of residual renal function (RRF) in peritoneal dialysis ( PD) patients is a powerful predictor of mortality. The present study was conducted to determine the predictors of faster decline of RRF in PD patients in Taiwan. METHODS: The study
LIAO, CHIA-TE;SHIAO, CHIH-CHUNG;HUANG, JENQ-WEN;HUNG, KUAN-YU;CHUANG, HSUEH-FANG;CHEN, YUNG-MING;WU, KWAN-DUN;TSAI, TUN-JUN, 廖家德;蕭志忠;黃政文;洪冠予;莊雪芳;陳永銘;吳寬墩;蔡敦仁   +1 more
core  

Comparison of the inflammatory, oxidative stress and endothelial markers between HD and HDF in patients with and without residual renal function.

, 2018
Comparison of the inflammatory, oxidative stress and endothelial markers between HD and HDF in patients with and without residual renal function.
Helen Aitkenhead (5409914), Ayşe Ağbaş (5409911), Hakan Ekmekçi (5409908), Nur Canpolat (689727), Lale Sever (689739), Mark Mayes (5409917), Alev Yılmaz (5409905), Franz Schaefer (143847), Salim Çalışkan (5409920), Rukshana Shroff (689740)   +9 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Progression rate of residual renal function in conservative treatment and early dialysis

, 1982
A retrospective comparative study was carried out in patients with chronic renal failure on conservative treatment (26 cases) and early dialysis (23 cases). The two groups were well matched for age, sex, etiology of renal disease and residual Ccr.
V. Bonomini, C. Feletti, A. Vangelista
core   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source