Results 41 to 50 of about 408,004 (261)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The effect of weld residual stresses and their re-distribution with crack growth during fatigue under constant amplitude loading [PDF]

, 2010
In this work the evolution of the residual stresses in a MIG-welded 2024-T3 aluminium alloy M(T) specimen during in situ fatigue crack growth at constant load amplitude has been measured with neutron diffraction.
Lin, J., Liljedahl, C. D. M., Fitzpatrick M, Edwards, L., Edwards, Lyndon, Fitzpatrick, Michael E., Zanellato, O., Fitzpatrick, M. E., Edwards L, Zanellato, Oliver, Liljedahl C, Liljedahl, C. David M., Lin J, Zanellato O   +13 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Comparison of joining efficiency and residual stresses in laser and laser hybrid welding [PDF]

, 2011
Laser welding is a high energy density process, which can produce welds with less energy input and thereby lower residual stress generation compared to arc welding processes.
Colegrove, Paul A., Paradowska AM, Ganguly S, Suder W, Ganguly, Supriyo, Colegrove P, Williams, Stewart W., Paradowska, A. M., Williams S, Suder, Wojciech   +9 more
core   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Synchrotron strain scanning for residual stress measurement in cold-drawn steel rods

, 2011
Cold-drawn steel rods and wires retain significant residual stresses as a consequence of the manufacturing process. These residual stresses are known to be detrimental for the mechanical properties of the wires and their durability in aggressive ...
M Elices, J Ruiz-Hervias, Elices Calafat, Manuel, Ruiz Hervías, Jesús, Atienza Riera, José Miguel, J M Atienza   +5 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The effect of residual stresses arising from laser shock peening on fatigue crack growth [PDF]

, 2010
Residual stresses have in the past been introduced to manipulate growth rates and shapes of cracks under cyclic loads. Previously, the effectiveness of shot peening in retarding the rate of fatigue crack growth was experimentally studied.
Brennan FP, Chahardehi A, Steuwer A, Brennan, Feargal P., Chahardehi, A., Steuwer, Axel, Brennan, F. P., Chahardehi, Amir Ebrahim   +7 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source