Results 111 to 120 of about 1,022,224 (293)
EngDespite significant advancements in understanding the effects of hardening modes, particularly shot peening, on the stress–strain state of materials, the determination of residual stress remains a considerable challenge, especially when temporal factors ...
Aleksey Bukaty +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Residual stress evolution analysis in AZ31 friction stir welds using X-Ray and neutron diffraction [PDF]
, 2009 This work was performed as a part of AEROMAG Project"Aeronautica lApplication of Wrought Magnesium" (project N°AST4-CT-2005 -516152) which was supported by the European Union.The authors wish to thank EADS-I W F, Suresnes for Friction Stir Welding,Robert
COMMIN, Loreleï +2 more
core
The effect of multiple bending of wire on the residual stresses of high carbon steel wires
Metalurgija, 2013 Steel tire cord, springs and rope wires belong to the group of metal products from which the low residual stresses are required. In this paper the effect of multiple bending of wire on residual stresses of high carbon steel wires has been assessed.
R. Kruzel, M. Suliga
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
, 2022 S.434-442The paper presents two methods for a nondestructive determination of thermally induced residual stresses in iron carbon steels and white cast iron.
Altpeter, I., Meyendorf, N., Kern, R.
core +1 more source
MachinesDuring the milling process of aramid honeycomb, residual stresses arise, which will affect the surface quality of the honeycomb. Studies have shown that reasonable processing techniques can reduce residual stresses, indicating a close relationship ...
Mingxing Zhang +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source