Results 181 to 190 of about 1,955,453 (343)

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

Molecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui, Matthew A. Cottam, Muhammad Bilal Mirza, Keeli B. Lewis, Kristen K. Ciombor, Mary Kay Washington, Kamran Idrees   +6 more
wiley   +1 more source

Roles in Binding and Chemistry for Conserved Active Site Residues in the Class 2 Dihydroorotate Dehydrogenase fromEscherichia coli

, 2009
Rebecca L. Fagan, Bruce A. Palfey
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Cheminformatic analysis of protein surfaces provides binding site insights and informs identification strategies. [PDF]

Future Med Chem
Milisavljević A, Pražnikar J, Bren U, Jukič M.   +3 more
europepmc   +1 more source

Electrochemical sensor determines antibiotic residues of Chloramphenicol in fresh milk using modified Glassy carbon electrode based on nZVI/GNPs/TCPP nanocomposite material synthesized by green chemistry method

Trung Dung Dang, Nguyễn Thùy Trang, Nguyen Thi Xuan Quynh, Nguyễn Lan Hương, Duong Duc La   +4 more
openalex   +2 more sources

Fire residues design: the chemistry behind synergistic effects in multicomponent polymeric systems

, 2017
Aleksandra Sut
openalex   +1 more source

Smelting of Bauxite Residue (Red Mud) in View of Iron and Selective Rare Earths Recovery

Journal of Sustainable Metallurgy, 2016
Chenna Rao Borra, B. Blanpain, Y. Pontikes, K. Binnemans, T. Van Gerven   +4 more
semanticscholar   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Characterization of C3' Epimerization of the Thioheptose Core in the Biosynthesis of Albomycin <i>δ</i> ₂ Catalyzed by the Radical <i>S</i>-Adenosylmethionine Enzyme AbmJ. [PDF]

ACS Catal
Zhao H, Chen Z, Franklin JL, Liu HW.
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source