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NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Dynamics-informed multigraph neural networks for protein thermostability prediction and residue-level interpretation. [PDF]

iScience
Chen YL, Chang SW.
europepmc   +1 more source

intDesc-AbMut: A Tool for Describing and Understanding How Antibody Mutations Impact Their Environmental Interactions. [PDF]

Comput Struct Biotechnol J
Chiba S, Ohta M, Yamane T, Okuno Y, Ikeguchi M.   +4 more
europepmc   +1 more source

evo3D R package: a spatial haplotype framework for structure-informed analysis of molecular evolution. [PDF]

Mol Biol Evol
Broyles BK, He Q.
europepmc   +1 more source

Review of the existing maximum residue levels for clopyralid according to Article 12 of Regulation (EC) No 396/2005. [PDF]

EFSA J
European Food Safety Authority (EFSA), Cabrera LC, Greco L, Nave S, Reich H, Ruocco S, Scarlato AP, Tiramani M, Zioga E.   +8 more
europepmc   +1 more source

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Proposal for field-based definition of soil bound pesticide residues

Science of the Total Environment, 2016
The environmental significance of soil bound pesticide residues (SBPR) is potentially large because approximately one third of the applied mass of the pesticides in agriculture ends up as SBPR. At EU level, there is little regulatory guidance available on the environmental risk assessment of SBPR in spite of some 50 years of SBPR research. This lack of
exaly   +4 more sources