Results 131 to 140 of about 304,445 (308)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Vinegar residue: a sustainable alternative to conventional feedstuffs for improving nutritional value and gut health in growing pigs

Animal Advances
The global scarcity of conventional foodstuffs such as corn, soybeans, and wheat has prompted the exploration of sustainable alternatives. Vinegar residue (VR), a byproduct of the food industry, appears as a potentially economical and nutritious feed ...
Ping Hu, Yunhan Wang, Long Yuan, Cuipeng Zhu, Xiaoyue Yuan, Miaonan Zhu, Kennedy Jerry Ogamune, Haoyu Liu, Demin Cai   +8 more
doaj   +1 more source

Molecular cancer prevention: Intercepting disease

Molecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco, Tej Pandya, Charles Swanton   +2 more
wiley   +1 more source

Quality Of Groundwaters In The Area Of The Łódź Basin [PDF]

, 2014
Published in: Origin of Relief of Central Poland and Its Anthropogenic Transformation in Łódź University Geographical Research, edited by. E.Kobojek, T.MarszałThe Łódź basin, and particularly its north-eastern fragment, has a very high economic ...
Ziułkiewicz, Maciej
core  

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

A comparative study on the production of ethanol from lignocellulosic biomass by chemical and biological method [PDF]

, 2011
Ethanol derived from non-edible biomass is renewable and a clean source of energy. It is independent of the food industry and it is economically feasible.
Madhan R, Rohit JP, Selvakumar K, Shaheed SM   +3 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Occurrence of antibiotic residues in raw fish Clarias gariepinus and Oreochromis niloticus from intensive rearing system in Benin

Veterinaria, 2019
An observational cross-sectional study was carriedy out to investigate antibiotic residues in Clarias gariepinus and Oreochromis niloticus from the intensive rearing system in Southern Benin.
S. E. P Mensah, H. Dakpogan, A. B. Aboh, K. Sika Chabi, M. Abléto, K. Y. K. B. Adjahoutonon, O. D. Koudandé, P. Sanders, G. A. Mensah   +8 more
doaj  

Oxygen application to chloride leaching of complex sulfide ores [PDF]

, 1987
The study investigates leaching of complex sulfide ores with simultaneous regeneration of the leaching solution and removal of dissolved iron to balance the iron concentration in the leaching process.
Chou, Kuo Tung
core