Results 131 to 140 of about 579,675 (213)

Interpretable machine learning uncovers structural determinants of Wnt-Wntless binding specificity from atomistic simulations. [PDF]

Commun Chem
Callahan TJ, Shi J, Cheng KJ, Sauer MA, Pogorelov TV, Capponi S.   +5 more
europepmc   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Alanine Rewires the Communication Pathways Established During the Allosteric Activation of Liver Pyruvate Kinase by Fructose Bisphosphate. [PDF]

J Chem Inf Model
Kumutima J, Yao XQ, Hamelberg D.
europepmc   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Transient tertiary structure in intrinsically disordered proteins revealed by multithermal enhanced sampling. [PDF]

Nat Commun
Streit JO, Invernizzi M, Bottaro S, Tamiola K, Lindorff-Larsen K.   +4 more
europepmc   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

An <i>In silico</i> analysis on the phosphorylation dependent structural and thermal stability of thermophilic proteins. [PDF]

Front Chem
Arunachalam S, Gnanasekaran R.
europepmc   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Accurate interdomain contacts in a mixed folded protein from NMR-guided coarse-grained simulations.

Phys Chem Chem Phys
Hobbs B, Limmer N, Clenshaw GL, Ossa F, Karamanos TK.   +4 more
europepmc   +1 more source

Convergent evolution of the N156K mutation in A(H1N1)pdm09 hemagglutinin contributes to antigenic drift and cluster transition. [PDF]

Emerg Microbes Infect
Tian Y, Jiang D, Ma W, Nie J, Li Q, Zhao C, Xu S, Huang W, Wang Y.   +8 more
europepmc   +1 more source