Results 171 to 180 of about 579,675 (213)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A Hydrophobic Cluster Modulates Long-Range Allostery in the TRMT2A RNA Recognition Motif. [PDF]

J Chem Inf Model
Khaled M, Johannknecht L, Palomino-Hernandez O.   +2 more
europepmc   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Standardized numbering and alignment of the KPC family of β-lactamases. [PDF]

Antimicrob Agents Chemother
Brunetti F, Marshall SH, Bethel CR, Hujer AM, Hujer KM, Haider S, Bush K, Bradford PA, Kreiswirth B, Spencer J, Ishii Y, Docquier J-D, Rossolini GM, Poirel L, Perilli M, Amicosante G, Galleni M, Vila AJ, Gutkind G, Palzkill T, Carattoli A, Tooke CL, Hinchliffe P, Schofield CJ, Iorga BI, Naas T, Chen Y, Arias C, Endimiani A, Papp-Wallace K, Shields RK, Tamma PD, Bonomo RA, Power P.   +33 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Intrinsically dominant conformational diversity in PDZ1 within the tandem PDZ1-PDZ2 of human syntenin-1 underlined by crystal structures. [PDF]

Protein Sci
Ando N, Hanazono Y, Sakuma K, Numoto N, Hamajima R, Tenno T, Oshima A, Ito N, Hiroaki H.   +8 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Modification of the existing maximum residue levels for acequinocyl in cane fruits and other small fruits and berries. [PDF]

EFSA J
European Food Safety Authority (EFSA), Bellisai G, Bernasconi G, Castellan I, Del Aguila M, Ferreira L, Lawal AI, Leuschner R, Mioč A, Szot M, Tiramani M, Verani A.   +11 more
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

PolyProline Predictor: A web server for empirical sequence-based prediction of polyproline II helices. [PDF]

Protein Sci
López-Sánchez R, Pantoja-Uceda D, Mompeán M, Laurents DV.   +3 more
europepmc   +1 more source