Design, Synthesis, and Evaluation of Coumarin-Rasagiline Hybrids as Multifunctional Neuroprotective Agents. [PDF]
ChemMedChemCarneiro A +8 more
europepmc +1 more source
Altered Cerebrospinal Fluid Tryptophan–Kynurenine Pathway Metabolism in Multiple System Atrophy
Movement Disorders, EarlyView.Abstract Background Alterations in tryptophan–kynurenine (TRP‐KYN) metabolism, which is associated with neuroinflammation, remain unclear in multiple system atrophy (MSA). Objective The aim was to investigate cerebrospinal fluid (CSF) TRP metabolites in MSA and their associations with other biomarkers.
Ryunosuke Nagao +8 more
wiley +1 more source
Synthetic Linear Lipopeptides and Lipopeptoids Induce Apoptosis and Oxidative Stress: In Vitro Cytotoxicity and SAR Evaluation Against Cancer Cell Lines. [PDF]
Pharmaceuticals (Basel)Hmedat A +5 more
europepmc +1 more source
Mathematical Methods in the Applied Sciences, EarlyView.We develop a full randomization of the classical hyper‐logistic growth model by obtaining closed‐form expressions for relevant quantities of interest, such as the first probability density function of its solution, the time until a given fixed population is reached, and the population at the inflection point.
Juan Carlos Cortés +2 more
wiley +1 more source
Conducting polymer-stabilized nanozymes alleviate sepsis-induced myocardial injury by inhibiting iron accumulation and lipid peroxidation. [PDF]
Nat CommunWu T +9 more
europepmc +1 more source
An Improved Air Film Model for Studying the Tilt Characteristics of Aerostatic Thrust Bearings
International Journal of Mechanical System Dynamics, EarlyView.ABSTRACT In this study, an improved mass‐spring model that treats the lubricating air film as distributed springs is proposed to calculate the static and dynamic angular stiffness of aerostatic thrust bearings. The proposed model refines the traditional mass‐spring model by introducing the spatially varying mechanical properties of the air film and the
Hui Zhuang, Jianguo Ding, Yu Chang
wiley +1 more source
Identification of Plasma-Generated Reactive Species in Water and Their DNA-Damaging Effects on Plasmid and Lymphocyte DNA. [PDF]
Int J Mol SciKyzek S +6 more
europepmc +1 more source
Review of Congenital Myasthenic Syndrome Caused by Pathogenic Variants in GFPT1
Muscle &Nerve, EarlyView.ABSTRACT Glutamine:fructose‐6‐phosphate transaminase 1 (GFPT1) catalyzes the first and rate‐limiting step of the hexosamine biosynthetic pathway (HBP) to generate UDP‐GlcNAc. GFPT1 exon 9 is specifically spliced in in striated muscles, which makes a long isoform of GFPT1 (GFPT1‐L).
Kinji Ohno +5 more
wiley +1 more source
Reactive Nitrogen Species and Fibrinogen: Exploring the Effects of Nitration on Blood Clots. [PDF]
Antioxidants (Basel)Nencini F +6 more
europepmc +1 more source
Muscle &Nerve, EarlyView.ABSTRACT Congenital myasthenic syndromes (CMS) are inherited disorders caused by mutations in genes encoding proteins essential for neuromuscular junction (NMJ) function. Pathogenic variants have been identified in more than 35 genes, underscoring the complexity of synaptic biology and the wide range of mechanisms that can compromise neuromuscular ...
Rocio‐Nur Villar‐Quiles +5 more
wiley +1 more source