Results 241 to 250 of about 2,155,054 (284)

Structural characterization of the HDV virion and its ribonucleoprotein. [PDF]

Proc Natl Acad Sci U S A
Itskanov S, Ary B, Mehra U, Lew I, Novikov N, Schmitz U, Holdorf MM, Beran RK, Lansdon EB.   +8 more
europepmc   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Luteolin Inhibits Invasion of Listeria monocytogenes by Interacting with SortaseA and InternalinB. [PDF]

Molecules
Liu J, Liu R, Pan H, Lu J, Liu Q, Wang G.   +5 more
europepmc   +1 more source

Allosteric effects of the coupling cation in melibiose transporter MelB. [PDF]

Elife
Hariharan P, Shi Y, Bakhtiiari A, Liang R, Viner R, Guan L.   +5 more
europepmc   +1 more source

Assessing the validity of leucine zipper constructs predicted by AlphaFold. [PDF]

Protein Sci
Mitic I, Rowell K, Litfin T, Michie KA, Jacques DA.   +4 more
europepmc   +1 more source

Therapeutic Perspectives of SIRT6 Regulation: Computational Analysis of Activation and Inhibition by Bioactive Molecules. [PDF]

J Mol Recognit
de Carvalho Matias ÉG, Bezerra KS, Junior WSC, Oliveira JIN, Galvão DS, Fulco UL.   +5 more
europepmc   +1 more source

Recent advances in structural and functional diversities of cancer lncRNA-encoded peptides: current opportunities and challenges for enhancing cancer diagnosis and treatment. [PDF]

Cancer Cell Int
Guo A, Wang S, Huang L, He Y, Xi Q, Craik DJ, Zhang J.   +6 more
europepmc   +1 more source