Results 31 to 40 of about 1,403,606 (305)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Water Balance Effect of Urbanization and Countermeasures for Enhancing Urban Water Security Resilience [PDF]
中国工程科学Over the past four decades, the rapid urbanization process in China, coupled with the impact of global climate change, has significantly affected the water balance in urban areas and their adjacent regions.
Qingfang Hu +4 more
doaj +1 more source
Enhancing OLAP Resilience at LinkedIn
CoRRReal-time OLAP datastores are critical infrastructure for modern enterprises, powering interactive analytics on petabyte-scale datasets with subsecond latency requirements. As these systems become integral to service architectures, maintaining strict SLAs under failures, load spikes, and cluster changes is as important as raw performance.
Praveen Chaganlal +9 more
openaire +3 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
EnergiesTraditional centralized highway energy systems exhibit significant resilience shortcomings in the face of climate change mitigation requirements and increasingly frequent extreme weather events.
Peiqiang Cui +7 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Data, social sciences, and health resilience [PDF]
, 2021 This STG Resilience Paper is part of the Commission Research Report and Interim Progress Report (June 2021) published by Reform for Resilience.There has been little health resilience in the face of the COVID-19 pandemic.
LEVINE, David K.
core +1 more source
ChildrenBackground: Youth experiencing homelessness (YEH) in East Asian Pacific (EAP) regions represent one of the most at-risk populations due to cultural and geographical factors. Effective mental health interventions, primarily researched in Western contexts,
Kimberley Cortez Ermita +1 more
doaj +1 more source
Short research report : exploring resilience development in a Taiwanese preschooler’s narrative : an emerging theoretical model [PDF]
, 2016 Short Research Report:Exploring resilience development in a Taiwanese preschooler’s narrative: An emerging theoretical model.peer ...
Kuan-Ling Olivia Lin +2 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source