Results 31 to 40 of about 896,165 (305)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Self-supported aluminum thin films produced by vacuum deposition process [PDF]

, 1966
Self-supported aluminum thin film is produced by vacuum depositing the film on a polyvinyl formal resin film and then removing the resin by radiant heating in the vacuum.
Neff, J. E., Timme, R. W.
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Influence of Cola-Based Soft Drinks on the Microhardness of Nanohybrid and Bulk Fill Composites [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Bulk fill composites have been introduced in the past few years and appear to solve some of the disadvantages of conventional composites such as polymerisation contraction and the consequent marginal microinfiltration.
Luis Henrique Brugim, Jaisson Cenci, Priscilla Do Monte Ribeiro Busato, Mauro Carlos Agner Busato, Veridiana Camilotti, Marcio José Mendonça   +5 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Epoxy and polyvinylchloride materials with fillers derived from rice waste [PDF]

E3S Web of Conferences
The article is dedicated to the study of silicate fillers on the base of rice production waste and their perspective application in epoxy and polyvinylchloride composite materials.
Gotlib Elena, Sokolova Alla, Zenitova Lyubov, Galimov Engel, Valeeva Alina   +4 more
doaj   +1 more source

Anterior Space Maintainer Incorporating a Pontic Derived from a Strip Crown [PDF]

Journal of Clinical and Diagnostic Research, 2018
Various designs of functional and aesthetic space maintainers have been used in the anterior region to replace missing upper primary anteriors. All of these had utilised pontics made of composite, acrylic or natural teeth.
Paul Chalakkal, Roshni Chandran, Kaveri Gandhi, Neil De Souza   +3 more
doaj   +1 more source

Investigation of the effect of double-walled carbon nanotubes on the curing reaction kinetics and shear flow of an epoxy resin [PDF]

, 2012
In this article, the effect of combined temperature-concentration and shear rate conditions on the rheology of double-walled carbon nanotubes (DWCNTs)/RTM6-Epoxy suspension was investigated to determine the optimum processing conditions.
Abdalla, Aduriz, Barrau, Battisti, Bauhöfer, Carreau, Deng, Dijkstra, Dutta, Eken, Eyring, Flahaut, Flahaut, Fulcher, Gojny, Gong, Gonzalez-Romero, Gupta, Han, Hobbie, Hough, Karkanas, Kazilas, Kim, Kim, Kovacs, Lee, Ma, Moniruzzaman, Nielsen, Park, Pascault, Puglia, Qiu, Qiu, Song, Sourour, Suave, Sui, Tammann, Tao, Terekhina, Terenzi, Torre, Veedu, Vogel, Wang, Williams, Xie, Yasuda, Zhou, Zhu, Špitalský   +52 more
core   +3 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source