Results 221 to 230 of about 475,541 (366)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Resist Newsletter, Sept. 2004

, 2004
Resist
core  

Improving interlimb coordination and paretic limb use after stroke using a novel robotic split-crank pedaling device: a cross-sectional study. [PDF]

J Neuroeng Rehabil
Ruopp TS, Schmit BD, Schindler-Ivens S.
europepmc   +1 more source

Resist resistance

This thesis explores changes in swallowing and communication following total laryngectomy (removal of the voice box). Chapter 1 outlines the anatomy and physiology of the pharynx and larynx, along with the functional changes that occur after the surgery.
openaire   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Resist Newsletter, May 2002

, 2001
Resist
core  

Combating Antimicrobial Resistance: A Pharmacist-Led PDCA Stewardship Program in a Tertiary Hospital [Letter]. [PDF]

Infect Drug Resist
Shan QQ.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Resist Newsletter, Apr. 1985

, 1983
Resist
core  

Co-Infection of <i>Chlamydia psittaci</i> and Methicillin-Resistant <i>Staphylococcus aureus</i> in Community-Acquired Pneumonia - A Case Report. [PDF]

Infect Drug Resist
Zhu SL, Pan LJ, Cheng WB, Zheng XF, Chen Y, Li M.   +5 more
europepmc   +1 more source